Page 21 - 《南京医科大学学报（自然科学版）》2026年第3期

第46卷第3期 杨 洁，孙惠苗，杨 宏，等. IDEAL⁃IQ及IVIM定量参数评价B⁃ALL患儿危险度分层及预测
2026年3月 早期化疗反应的初步研究［J］. 南京医科大学学报（自然科学版），2026，46（3）：324-332 ·329 ·

A B C D
A：PDFF parameter of CR children before chemotherapy. B：PDFF parameter of CR children after chemotherapy. C：PDFF parameter of N⁃CR chil⁃
dren before chemotherapy. D：PDFF parameter of N⁃CR children after chemotherapy. The PDFF values of CR children after chemotherapy were higher
than those of N⁃CR children.
图4 CR及N⁃CR组B⁃ALL患儿腰椎PDFF参数图
Figure 4 Lumbar PDFF parameters of B⁃ALL children in the CR and N⁃CR groups

应的ROC曲线分析 （95%CI：0.968~0.926）；化疗前D值及D 值曲线下面
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以N⁃CR 组作为诊断状态变量分别进行化疗后 积分别为 AUC=0.706（95%CI：0.559~0.853）、AUC=
PDFF、化疗前 D 值、化疗前 D 值、化疗前 D+D 值联 0.600（95%CI：0.439~0.761）；化疗前 D+D 值预测
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合指标的 ROC 分析，化疗后 PDFF 值的 AUC=0.807 N⁃CR的AUC=0.817（表4，图5）。
表4 IDEAL⁃IQ及IVIM序列参数预测B⁃ALL早期化疗反应ROC分析
Table 4 ROC analysis of IDEAL⁃IQ and IVIM sequence parameter prediction of early chemotherapy response in B⁃ALL
Indicator AUC 95%CI Cut⁃off value Sensitivity Specificity
After chemotherapy PDFF 0.802 0.677-0.926 21.74 0.74 0.80
Before chemotherapy D 0.706 0.559-0.853 0.430 0.70 0.68
Before chemotherapy D * 0.600 0.439-0.761 31.79 0.96 0.28
Before chemotherapy D+D * 0.817 0.699-0.936 0.440 0.78 0.76

A 1.0 B 1.0

0.8 0.8

Sensitivity 0.6 Sensitivity 0.6

0.4
0.4
Before chemotherapy D+D *
AUC=0.817
After chemotheraphy PDFF Before chemotherapy D
0.2 0.2 AUC=0.706
AUC=0.802 Before chemotherapy D *
AUC=0.600
Reference line
0 0
0 0.2 0.4 0.6 0.8 1.0 0 0.2 0.4 0.6 0.8 1.0
1-specificity 1-specificity
A：ROC curve of PDFF predicting N⁃CR in B⁃ALL children after induction chemotherapy post⁃chemotherapy. B：ROC curve of pre⁃chemotherapy
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D，pre⁃chemotherapy D ，and combined pre⁃chemotherapy D with D for predicting N⁃CR in B⁃ALL children after induction chemotherapy post⁃
chemotherapy.
图5 化疗后PDFF、化疗前D及D 值预测B⁃ALL患儿早期化疗疗效的ROC曲线图
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Figure 5 ROC curve of PDFF and D and D values predicting early chemotherapy efficacy in B⁃ALL children after
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chemotherapy