Page 75 - 《南京医科大学学报（自然科学版）》2026年第3期

第46卷第3期 杨 燕，胡琴琴，刘 裔，等. 利福平和利福布汀对rpoB基因突变而表型敏感的结核菌耐药性研究［J］.
2026年3月 南京医科大学学报（自然科学版），2026，46（3）：375-383 ·383 ·

Microbiol Spectr，2024，12（1）：e0163123 rpoB gene mutation and clinical outcomes of Staphylococ⁃
［19］WEI L Q，CHEN J，DENG Z，et al. Genetic diversity and cus species isolates from prosthetic joint infections in Re⁃
transmission pattern of multidrug ⁃ resistant tuberculosis public of Korea［J］. J Glob Antimicrob Resist，2022，28：
based on whole⁃genome sequencing in Wuhan，China［J］. 43-48
Front Public Health，2025，13：1442987 ［30］RIGDEN D J. The histidine phosphatase superfamily：
［20］CASTRO ⁃ RODRIGUEZ B，ESPINOZA ⁃ ANDRADE S， Structure and function［J］. Biochem J，2008，409（2）：
FRANCO⁃SOTOMAYOR G，et al. A first insight into tu⁃ 333-348
berculosis transmission at the border of Ecuador and Co⁃ ［31］METCALFE R D，MARTINEZ FIESCO J A，BONET ⁃
lombia：a retrospective study of the population structure PONCE L，et al. Structure and regulation of full⁃length hu⁃
of Mycobacterium tuberculosis in Esmeraldas province［J］. man leucine⁃rich repeat kinase 1［J］. Nat Commun，2023，
Front Public Health，2024，12：1343350 14（1）：4797
［21］LE HANG N T，HIJIKATA M，MAEDA S，et al. Whole ge⁃ ［32］XU G，LIU H C，JIA X D，et al. Mechanisms and detec⁃
nome sequencing，analyses of drug resistance⁃conferring tion methods of Mycobacterium tuberculosis rifampicin
mutations，and correlation with transmission of Mycobacte⁃ resistance：the phenomenon of drug resistance is com⁃

rium tuberculosis carrying katG⁃S315T in Hanoi，Viet⁃ plex［J］. Tuberculosis（Edinb），2021，128：102083
nam［J］. Sci Rep，2019，9：15354 ［33］GOOSSENS S N，SAMPSON S L，VAN RIE A. Mecha⁃
［22］CHEN L，GAN X，LI N N，et al. rpoB gene mutation pro⁃ nisms of drug⁃induced tolerance in Mycobacterium tuber⁃
file in rifampicin ⁃ resistant Mycobacterium tuberculosis culosis［J］. Clin Microbiol Rev，2020，34（1）：e00141-20
clinical isolates from Guizhou，one of the highest inci⁃ ［34］FLOSS H G，YU T W. Rifamycin⁃mode of action，resis⁃
dence rate regions in China［J］. J Antimicrob Chemother， tance，and biosynthesis［J］. Chem Rev，2005，105（2）：
2010，65（6）：1299-1301 621-632
［23］QADIR M，TAHSEEN S，MCHUGH T D，et al. Profiling ［35］TREBOSC V，KEMMER C，LOCIURO S，et al. Rifabutin
and identification of novel rpoB mutations in rifampicin⁃ for infusion（BV100）for the treatment of severe carbapen⁃
resistant Mycobacterium tuberculosis clinical isolates from em⁃resistant Acinetobacter baumannii infections［J］. Drug
Pakistan［J］. J Infect Chemother，2021，27（11）：1578- Discov Today，2021，26（9）：2099-2104
1583 ［36］BURMAN W J，GALLICANO K，PELOQUIN C. Compara⁃
［24］ZENG M C，JIA Q J，TANG L M. rpoB gene mutations in tive pharmacokinetics and pharmacodynamics of the rifa⁃
rifampin ⁃ resistant Mycobacterium tuberculosis isolates mycin antibacterials［J］. Clin Pharmacokinet，2001，40
from rural areas of Zhejiang，China［J］. J Int Med Res， （5）：327-341
2021，49（3）：300060521997596 ［37］NAHID P，MASE S R，MIGLIORI G B，et al. Treatment of
［25］LEAVITT S V，JACOBSON K R，RAGAN E J，et al. De⁃ drug⁃resistanttuberculosis.anofficialATS/CDC/ERS/IDSA
centralized care for rifampin⁃resistant tuberculosis，west⁃ clinical practice guideline［J］. Am J Respir Crit Care
ern cape，South Africa［J］. Emerg Infect Dis，2021，27 Med，2019，200（10）：e93-e142
（3）：728-739 ［38］LIN W H，LEE W T，TSAI H Y，et al. Disputed rpoB mu⁃
［26］SADOVSKA D，NODIEVA A，POLE I，et al. Discordance tations in Mycobacterium tuberculosis and tuberculosis
between phenotypic and WGS ⁃ based drug susceptibility treatment outcomes［J］. Antimicrob Agents Chemother，
testing results for some anti ⁃ tuberculosis drugs：a snap⁃ 2021，65（7）：e0157320
shot study of paired Mycobacterium tuberculosis isolates ［39］李 广，李力韬，崔 旭，等. 核酸检测指导个体化耐药
with small genetic distance［J］. Infect Drug Resist，2024， 脊柱结核治疗［J］. 中国矫形外科杂志，2021，29（1）：
17：3289-3307 37-41
［27］LI M C，WANG X Y，XIAO T Y，et al. rpoB mutations are LI G，LI L T，CUI X，et al. Nucleic acid testing guides in⁃
associated with variable levels of rifampin and rifabutin dividualized treatment of drug⁃resistant spinal tuberculo⁃
resistance in Mycobacterium tuberculosis［J］. Infect Drug sis［J］. Orthopedic Journal of China，2021，29（1）：37-41
Resist，2022，15：6853-6861 ［40］FARZANEH S，NOROUZI F，FAZELI H，et al. Novel mu⁃
［28］HUANG W J，LEE M K T，SIN A T K，et al. Evaluation of tation in efflux pump Rv1258c（Tap）gene in drug resistant
Xpert MTB/RIF Ultra assay for detection of Mycobacteri⁃ clinical isolates of Mycobacterium tuberculosis in Iran［J］. J
um tuberculosis and rifampicin resistance［J］. Pathology， Infect Dev Ctries，2024，18（2）：243-250
2023，55（5）：688-697 （收稿：2025-10-14；修回：2025-12-20；录用：2025-12-30）
［29］LEE Y，KIM S S，CHOI S M，et al. Rifamycin resistance， （本文编辑：陈汐敏）