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［38］吕 转，王亚敏，刘瑞东，等. 肠道微生物⁃肠⁃脑轴与卒 Front Neurosci，2021，15：578922
中后认知障碍的相关性研究进展［J］. 解放军医学杂 ［49］GHASEMI A. Quantitative aspects of nitric oxide produc⁃
志，2024，49（9）：1073-1079 tion from nitrate and nitrite［J］. EXCLI J，2022，21：470-
LYU Z，WANG Y M，LIU R D，et al. Research progress 486
on the correlation between gut microbiota⁃gut⁃brain axis ［50］ MADER M D，CZORLICH P. The role of L ⁃ arginine
and post⁃stroke cognitive impairment［J］. Medical Journal metabolism in neurocritical care patients［J］. Neural
of Chinese People’s Liberation Army，2024，49（9）： Regen Res，2022，17（7）：1446

1073-1079 ［51］STEED M M，TYAGI S C. Mechanisms of cardiovascular
［39］YANG Y，SHI G J，GE Y Y，et al. Accumulated BCAAs remodeling in hyperhomocysteinemia［J］. Antioxid Redox
and BCKAs contribute to the HFD⁃induced deterioration Signal，2011，15（7）：1927-1943
of Alzheimer ’s disease via a dysfunctional TREM2⁃ ［52］CAUDILL M A，WANG J C，MELNYK S，et al. Intracellu⁃
related reduction in microglial β⁃amyloid clearance［J］. J lar S⁃adenosylhomocysteine concentrations predict global
Neuroinflammation，2024，21（1）：327 DNA hypomethylation in tissues of methyl⁃deficient cysta⁃
［40］ZUO X R，ZHAO R，WU M M，et al. Multi⁃omic profiling thionine β⁃synthase heterozygous mice［J］. J Nutr，2001，
of sarcopenia identifies disrupted branched⁃chain amino 131（11）：2811-2818
acid catabolism as a causal mechanism and therapeutic ［53］ZHANG X Y，HUANG Z B，XIE Z A，et al. Homocysteine
target［J］. Nat Aging，2025，5（3）：419-436 induces oxidative stress and ferroptosis of nucleus pulpo⁃
［41］SHNITKO T A，TAYLOR S C，STRINGFIELD S J，et al. sus via enhancing methylation of GPX4［J］. Free Radic
Acute phenylalanine/tyrosine depletion of phasic dopa⁃ Biol Med，2020，160：552-565
mine in the rat brain［J］. Psychopharmacology，2016，233 ［54］PANDAY S，TALREJA R，KAVDIA M. The role of gluta⁃
（11）：2045-2054 thione and glutathione peroxidase in regulating cellular
［42］RAUSELL D，GARCÍA⁃BLANCO A，CORRECHER P，et level of reactive oxygen and nitrogen species［J］. Micro⁃
al. Newly validated biomarkers of brain damage may shed vasc Res，2020，131：104010
light into the role of oxidative stress in the pathophysiolo⁃ ［55］ ZHOU R L，ZHAI W J，MENG L J，et al. Serum multi⁃
gy of neurocognitive impairment in dietary restricted trace elements and post ⁃ stroke cognitive impairment：a
phenylketonuria patients［J］. Pediatr Res，2019，85（2）： prospective observational cohort study［J］. Transl Psychi⁃
242-250 atry，2025，15：222
［43］ LOVELACE M D，VARNEY B，SUNDARAM G，et al. ［56］ TOMAS⁃SANCHEZ C，BLANCO⁃ALVAREZ V M，GON⁃
Recent evidence for an expanded role of the kynurenine ZALEZ⁃BARRIOS J A，et al. Prophylactic zinc and thera⁃
pathway of tryptophan metabolism in neurological diseas⁃ peutic selenium administration in adult rats prevents long⁃
es［J］. Neuropharmacology，2017，112：373-388 term cognitive and behavioral sequelae by a transient
［44］ MOR A，TANKIEWICZ⁃KWEDLO A，CIWUN M，et al. ischemic attack［J］. Heliyon，2024，10（9）：e30017
Kynurenines as a novel target for the treatment of inflam⁃ ［57］ DANCHIN A. Zinc，an unexpected integrator of metabo⁃
matory disorders［J］. Cells，2024，13（15）：1259 lism?［J］. Microb Biotechnol，2020，13（4）：895-898
［45］HEISLER J M，O’CONNOR J C. Indoleamine 2，3⁃dioxy⁃ ［58］ARISAWA K，NATORI M，HIRANUMA T，et al. NRF2⁃
genase ⁃ dependent neurotoxic kynurenine metabolism dependent suppression of selenoprotein P expression
mediates inflammation ⁃ induced deficit in recognition promotes intracellular selenium metabolic remodeling
memory［J］. Brain Behav Immun，2015，50：115-124 and upregulation of antioxidant selenoproteins in hepato⁃
［46］ ZHANG D Y，HUA Z Y，LI Z J. The role of glutamate and cellular carcinoma［J］. Redox Biol，2025，86：103821
glutamine metabolism and related transporters in nerve ［59］ORTIZ ⁃ SALGUERO C，ROMERO ⁃ BERNAL M，
cells［J］. CNS Neurosci Ther，2024，30（2）：e14617 GONZÁLEZ ⁃ DÍAZ Á ，et al. Hyperhomocysteinemia ：
［47］WU W L，GONG X X，QIN Z H，et al. Molecular mecha⁃ underlying links to stroke and hydrocephalus ，with a
nisms of excitotoxicity and their relevance to the patho⁃ focus on polyphenol ⁃ based therapeutic approaches［J］.
genesis of neurodegenerative diseases⁃an update［J］. Acta Nutrients，2025，17（1）：40
Pharmacol Sin，2025，46（12）：3129-3142 ［60］SIKORA M，BRETES E，PERŁA⁃KAJÁN J，et al. Homo⁃
［48］LIMÓN I D，ANGULO⁃CRUZ I，SÁNCHEZ⁃ABDON L，et cysteine thiolactone and other sulfur ⁃ containing amino
al. Disturbance of the glutamate⁃glutamine cycle，second⁃ acid metabolites are associated with fibrin clot properties
ary to hepatic damage，compromises memory function［J］. and the risk of ischemic stroke［J］. Sci Rep，2024，14：