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第46卷第4期         任琼迪,苏凯奇,张 铭. 氨基酸代谢紊乱在卒中后认知障碍中的作用机制及研究进展[J].
                  2026年4月                    南京医科大学学报(自然科学版),2026,46(4):499-511,519                     ·511 ·


                    11222                                              events: a systematic review and meta⁃analysis[J]. Front
               [61] ZHENYUKH O,GONZÁLEZ⁃AMOR M,RODRIGUES⁃              Neurol,2023,14:1144584
                    DIEZ R R,et al. Branched⁃chain amino acids promote  [73] ZHANG P P,ZHANG Y R. Association of homocysteine
                    endothelial dysfunction through increased reactive oxygen  with acute stroke and its subtypes in the Chinese popula⁃
                    species generation and inflammation[J]. J Cellular Mo⁃  tion[J]. Neuropsychiatr Dis Treat,2023,19:1435-1442
                    lecular Medi,2018,22(10):4948-4962           [74] WANG X,PENG Y,ZHOU H Y,et al. The effects of
               [62]FIEDLER L. The DDAH/ADMA pathway is a critical      enriched rehabilitation on cognitive function and serum
                    regulator of NO signalling in vascular homeostasis[J].  glutamate levels post⁃stroke[J]. Front Neurol,2022,13:
                    Cell Adhes Migr,2008,2(3):149-150                  829090
               [63]WANG X P,YAN D,JIN X P,et al. The role of amino  [75]MENG X G,LI N,GUO D Z,et al. High plasma glutamate
                    acid metabolism alterations in acute ischemic stroke:  levels are associated with poor functional outcome in
                    from mechanism to application[J]. Pharmacol Res,2024,  acute ischemic stroke[J]. Cell Mol Neurobiol,2015,35
                    207:107313                                        (2):159-165
               [64]MCKENNA M C. The glutamate ⁃ glutamine cycle is not  [76]ROUSSEAU A F,MARTINDALE R. Nutritional and met⁃
                    stoichiometric:fates of glutamate in brain[J]. J Neurosci  abolic modulation of inflammation in critically ill patients:
                    Res,2007,85(15):3347-3358                          a narrative review of rationale,evidence and grey areas[J].
               [65]FERREIRA A V,DOMÍNGUEZ ⁃ ANDRÉS J,MERLO             Ann Intensive Care,2024,14(1):121
                    PICH L M,et al. Metabolic regulation in the induction of  [77]CHEN J M,HERRUP K. Glutamine acts as a neuroprotec⁃
                    trained immunity[J]. Semin Immunopathol,2024,46(3):7  tant against DNA damage,beta ⁃ amyloid and H 2O2 ⁃ in⁃
               [66]ANDERSEN J V. The glutamate/GABA⁃glutamine cycle:   duced stress[J]. PLoS One,2012,7(3):e33177
                    insights,updates,and advances[J]. J Neurochem,2025,  [78]BARANOVICOVA E,KALENSKA D,LEHOTSKY J. Glu⁃
                    169(3):e70029                                      tamate/GABA/glutamine ratios in intact and ischemia
               [67]王国军,雷海军,杨 莉,等. 补阳还五汤联合个体化认知                         reperfusion challenged rat brain subregions,the effect of
                    训练对脑卒中后认知功能障碍及神经功能的影响[J]. 中                        ischemic preconditioning[J]. Metab Brain Dis,2025,40
                    华全科医学,2024,22(11):1938-1941,1975                  (2):121
                    WANG G J,LEI H J,YANG L,et al. Effect of Buyang  [79]SHEN J J,GUO H M,LIU S J,et al. Aberrant branched⁃
                    Huanwu Decoction combined with individualized cogni⁃  chain amino acid accumulation along the microbiota ⁃
                    tive training on post ⁃ stroke cognitive dysfunction and  gut⁃brain axis:crucial targets affecting the occurrence and
                    neurological function[J]. Chinese Journal of General  treatment of ischaemic stroke[J]. British J Pharmacology,
                    Practice,2024,22(11):1938-1941,1975                2023,180(3):347-368
               [68]WANG L S,HUANG Y W,WU J H,et al. Effect of Buy⁃  [80]PARK M K,LEE S J,CHOI E,et al. The effect of branched
                    ang Huanwu decoction on amino acid content in cerebro⁃  chain amino acid supplementation on stroke⁃related sarco⁃
                    spinal fluid of rats during ischemic/reperfusion injury[J].  penia[J]. Front Neurol,2022,13:744945
                    J Pharm Biomed Anal,2013,86:143-150          [81]GROSSE G M,SCHWEDHELM E,WORTHMANN H,et
               [69]KIM J H,CHO S Y,LEE J H,et al. Neuroprotective      al. Arginine derivatives in cerebrovascular diseases:
                    effects of ginsenoside Rg3 against homocysteine⁃induced  mechanisms and clinical implications[J]. Int J Mol Sci,
                    excitotoxicity in rat hippocampus[J]. Brain Res,2007,  2020,21(5):1798

                    1136:190-199                                 [82]KALISZEWSKA A,STRUCZYNSKI P,BACZEK T,et al.
               [70]YUE R C,LI X,CHEN B Y,et al. Astragaloside Ⅳ atten⁃  Comprehensive analysis and comparison of amino acid
                    uates glutamate ⁃ induced neurotoxicity in PC12 cells  levels in cerebrospinal fluid and plasma of children with
                    through raf⁃MEK⁃ERK pathway[J]. PLoS One,2015,10   leukemia by the LC ⁃ MS technique[J]. Int J Mol Sci,
                    (5):e0126603                                       2025,26(5):1888
               [71]FAN X S,WANG E S,HE J X,et al. Ligustrazine protects  [83]WANG Y Y,SUN Y,WANG Y,et al. Urine metabolomics
                    homocysteine⁃induced apoptosis in human umbilical vein  phenotyping and urinary biomarker exploratory in mild
                    endothelial cells by modulating mitochondrial dysfunc⁃  cognitive impairment and Alzheimer’s disease[J]. Front
                    tion[J]. J Cardiovasc Trans Res,2019,12(6):591-599  Aging Neurosci,2023,15:1273807
               [72]PINZON R T,WIJAYA V O,VERONICA V. The role of  [84]DENG X H,WU J L,JIANG Z W,et al. Detection of
                    homocysteine levels as a risk factor of ischemic stroke                      (下转第519页)
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