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第46卷第5期          刘   婷,杜子伟,徐文健,等. HSG影像特征联合临床特征诊断宫腔粘连的效能研究[J].
                  2026年5月                     南京医科大学学报(自然科学版),2026,46(5):629-636                         ·635 ·


                用应严格遵循不孕症诊疗规范。                                   [3] HOOKER A B,LEMMERS M,THURKOW A L,et al. Sys⁃
                    整合HSG影像特征与临床指标,可有效克服单                             tematic review and meta ⁃ analysis of intrauterine adhe⁃
                一检查的局限性,进一步彰显HSG在IUA分型诊断                              sions after miscarriage:prevalence,risk factors and long⁃
                                                                      term reproductive outcome[J]. Hum Reprod Update,
                中的独特优势。因此建议不孕症且怀疑存在IUA的
                                                                      2014,20(2):262-278
                患者建立阶梯式诊断流程:以HSG联合临床特征进
                                                                 [4] MORTIMER R M,LANES A,SROUJI S S,et al. Treat⁃
                行 IUA 诊断分型及输卵管通畅度评估,三维超声补
                                                                       ment of intrauterine adhesions and subsequent pregnancy
                充内膜血流分析,最终由宫腔镜确诊,从而平衡诊
                                                                       outcomes in an in vitro fertilization population[J]. Am J
                断效率与医疗成本。本研究存在的局限性:首先,                                 Obstet Gynecol,2024,231(5):536.e1-536.e10
                回顾性研究设计可能存在选择偏倚;其次,未系统                           [5] TSAI N C,HSIAO Y Y,SU Y T,et al. The efficacy of early
                比较 HSG 与三维超声对不同分型 IUA 的鉴别能                             office hysteroscopy in preventing intrauterine adhesions
                力。最后,本研究基于单中心数据,需多中心验证                                 after abortion:a randomized controlled trial[J]. BMC Wo⁃
                以提高外部适用性。后续将纳入更多预测因子(如                                 mens Health,2024,24(1):400
                炎症标志物等),提升对中度 IUA 的鉴别能力,并探                       [6] PENG E,ZENG Y Y,HE D,et al. Intrauterine infusion of
                                                                       autologous endometrial stem cells for the treatment of
                索多模态诊断系统,结合HSG的形态特征与超声血
                                                                       moderate and severe intrauterine adhesions:a before⁃and⁃
                流参数,以实现更为精确的无创评估,从而进一步
                                                                       after study[J]. Stem Cell Res Ther,2025,16(1):219
                丰富和完善IUA的个体化诊疗体系。
                                                                 [7] ZHAO X P,GUAN X M,ZHANG B Y,et al. Three⁃dimen⁃
                    综上所述,本研究的HSG影像特征联合临床特                              sional transvaginal ultrasound offers superior live birth
                征能很好地预测 IUA 的价值以及分型,有助于尽早                              prediction after hysteroscopic adhesiolysis[J]. Reprod
                识别 IUA 患者,并为其提供更为个性化的诊疗及助                              Biomed Online,2025,51(1):104808
                孕方案。                                             [8] IGBODIKE E P,BADEJOKO O O,FASUBAA O B,et al.
                   利益冲突声明:                                             Correlation between hysterosalpingography diagnosis and
                   所有作者声明无利益冲突。                                        final hysterolaparoscopy with dye⁃test diagnosis in women
                   Conflict of Interests:                              with utero⁃tubal infertility:a cross⁃sectional study of the
                                                                       implication for which test should be the first⁃line investi⁃
                   The authors declared no competing interests.
                   作者贡献声明:                                             gation[J]. SAGE Open Med,2022,10:1-8
                   刘婷负责研究设计、数据收集整理与分析以及论文的撰                      [9] MATHEWS D M,PEART J M,SIM R G,et al. Iodine and
                写工作。杜子伟负责数据分析、论文修订。徐文健负责研究                             other factors associated with fertility outcome following oil⁃
                设计、论文审阅及修改、指导。鲁景元和李秀玲负责论文的                             soluble contrast medium hysterosalpingography:a pro⁃
                审阅、指导。                                                 spective cohort study[J]. Front Endocrinol(Lausanne),
                   Author’s Contributions:                             2024,15:1257888
                                                                 [10]王    银,杜子伟,徐文健,等. 原发不孕症患者对不同碘
                   LIU Ting was responsible for research design,data process⁃
                                                                       油对比剂在子宫输卵管造影后结果的比较分析[J]. 实
                ing and analysis,and manuscript drafting. DU Ziwei was respon⁃
                                                                       用放射学杂志,2024,40(9):1514-1517
                sible for data analysis and critical revision of the manuscript.
                                                                       WANG Y,DU Z W,XU W J,et al. Comparison analysis
                XU Wenjian was responsible for study design,critical revision
                                                                       of the results of hysterosalpingography with different io⁃
                of the manuscript,and guidance on the research. LU Jingyuan
                                                                       dized oil⁃based contrast medium in primary infertility pa⁃
                and LI Xiuling were responsible for critical review of the manu⁃
                                                                       tients[J]. Journal of Practical Radiology,2024,40(9):
                script and guidance.
                                                                       1514-1517
               [参考文献]
                                                                 [11]TOMA L M,SOCOLOV D,MATEI D,et al. Intrauterine
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                    factor of female infertility[J]. Front Med(Lausanne),  spectives[J]. Diagnostics(Basel),2025,15(8):955
                    2021,8:720401                                [12]The American Fertility Society classifications of adnexal
               [2] XIN L B,WEI C,TONG X M,et al. In situ delivery of   adhesions,distal tubal occlusion,tubal occlusion second⁃
                    apoptotic bodies derived from mesenchymal stem cells via  ary to tubal ligation,tubal pregnancies,müllerian anoma⁃

                    a hyaluronic acid hydrogel:a therapy for intrauterine  lies and intrauterine adhesions[J]. Fertil Steril,1988,49
                    adhesions[J]. Bioact Mater,2021,12:107-119        (6):944-955
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