Page 161 - 南京医科大学自然版
P. 161
第46卷第6期 徐玮婧,雷 洋,王朝霞. 糖代谢重编程在肿瘤耐药中的研究进展[J].
2026年6月 南京医科大学学报(自然科学版),2026,46(6):935-944 ·943 ·
signaling[J]. Cancer Res,2022,82(5):831-845 [40]HOLLOWAY R W,MARIGNANI P A. Targeting mTOR
[28]HOU L,ZHAO Y,SONG G Q,et al. Interfering cellular and glycolysis in HER2⁃positive breast cancer[J]. Can⁃
lactate homeostasis overcomes Taxol resistance of breast cers(Basel),2021,13(12):2922
cancer cells through the microRNA⁃124⁃mediated lactate [41]LIU H,LYU H,JIANG G,et al. ALKBH5⁃mediated m6A
transporter(MCT1)inhibition[J]. Cancer Cell Int,2019, demethylation of GLUT4 mRNA promotes glycolysis and
19:193 resistance to HER2⁃targeted therapy in breast cancer[J].
[29]DONG Q,ZHOU C,REN H,et al. Lactate⁃induced MRP1 Cancer Res,2022,82(21):3974-3986
expression contributes to metabolism⁃based etoposide re⁃ [42]LI W,ZHOU C,YU L,et al. Tumor⁃derived lactate pro⁃
sistance in non⁃small cell lung cancer cells[J]. Cell Com⁃ motes resistance to bevacizumab treatment by facilitating
mun Signal,2020,18(1):167 autophagy enhancer protein RUBCNL expression through
[30]DUAN R,ZHAI Y,WANG Q,et al. LINC01764 promotes histone H3 lysine 18 lactylation(H3K18la)in colorectal
colorectal cancer cells proliferation,metastasis,and 5⁃flu⁃ cancer[J]. Autophagy,2024,20(1):114-130
orouracil resistance by regulating glucose and glutamine [43]PASSARO A,BRAHMER J,ANTONIA S,et al. Manag⁃
metabolism via promoting c ⁃ MYC translation[J]. Med⁃ ing resistance to immune checkpoint inhibitors in lung
Comm,2024,5(11):e70003 cancer:treatment and novel strategies[J]. JCO,2022,40
[31]XI Y,YUAN P,LI T,et al. hENT1 reverses chemoresis⁃ (6):598-610
tance by regulating glycolysis in pancreatic cancer[J]. [44]BAGCHI S,YUAN R,ENGLEMAN E G. Immune check⁃
Cancer Lett,2020,479:112-122 point inhibitors for the treatment of cancer:clinical im⁃
[32]LU C,QIAO P,SUN Y,et al. Positive regulation of pact and mechanisms of response and resistance[J]. Annu
PFKFB3 by PIM2 promotes glycolysis and paclitaxel re⁃ Rev Pathol Mech Dis,2021,16(1):223-249
sistance in breast cancer[J]. Clin Transl Med,2021,11 [45]DANESHMANDI S,WEGIEL B,SETH P. Blockade of
(4):e400 lactate dehydrogenase⁃A(LDH⁃A)improves efficacy of anti
[33]XU M,CHEN S,YANG W,et al. FGFR4 links glucose ⁃programmed cell death⁃1(PD⁃1)therapy in melanoma[J].
metabolism and chemotherapy resistance in breast can⁃ Cancers(Basel),2019,11(4):450
cer[J]. Cell Physiol Biochem,2018,47(1):151-160 [46]QIAO T,XIONG Y,FENG Y,et al. Inhibition of LDH⁃A
[34]ZHAO M,ZHANG Y,LI L,et al. KHDRBS3 accelerates by oxamate enhances the efficacy of anti⁃PD⁃1 treatment
glycolysis and promotes malignancy of hepatocellular car⁃ in an NSCLC humanized mouse model[J]. Front Oncol,
cinoma via upregulating 14 ⁃ 3 ⁃ 3ζ[J]. Cancer Cell Int, 2021,11:632364
2023,23(1):244 [47]CAPPELLESSO F,ORBAN M P,SHIRGAONKAR N,et
[35]YOU Q,WANG J,YU Y,et al. The histone deacetylase al. Targeting the bicarbonate transporter SLC4A4 over⁃
SIRT6 promotes glycolysis through the HIF⁃1α/HK2 sig⁃ comes immunosuppression and immunotherapy resistance
naling axis and induces erlotinib resistance in non⁃small in pancreatic cancer[J]. Nat Cancer,2022,3(12):1464-
cell lung cancer[J]. Apoptosis,2022,27(11⁃12):883- 1483
898 [48]CHEN T,XU Z G,LUO J,et al. NSUN2 is a glucose sen⁃
[36]ZHANG C,ZHOU W,XU H,et al. Cancer⁃associated fi⁃ sor suppressing cGAS/STING to maintain tumorigenesis
broblasts promote EGFR⁃TKI resistance via the CTHRC1/ and immunotherapy resistance[J]. Cell Metabolism,
glycolysis/H3K18la positive feedback loop[J]. Oncogene, 2023,35(10):1782-1798
2025,44(19):1400-1414 [49]YU T,LIU Z,TAO Q,et al. Targeting tumor ⁃ intrinsic
[37]ZHANG T,PAN Z,GAO J,et al. Branched⁃chain amino SLC16A3 to enhance anti ⁃ PD ⁃ 1 efficacy via tumor im⁃
acid transaminase 1 confers EGFR⁃TKI resistance through mune microenvironment reprogramming[J]. Cancer Lett,
epigenetic glycolytic activation[J]. Sig Transduct Target 2024,589:216824
Ther,2024,9(1):216 [50]XU W,ZHOU B,WANG P,et al. N6 ⁃ methyladenosine
[38]DI S C,CHEN W J,YANG W,et al. DEPDC1 as a meta⁃ modification of 3’tRF⁃AlaAGC impairs PD⁃1 blockade ef⁃
bolic target regulates glycolysis in renal cell carcinoma ficacy by promoting lactic acid accumulation in the tumor
through AKT/mTOR/HIF1α pathway[J]. Cell Death Dis, microenvironment of gastric carcinoma[J]. Drug Resis⁃
2024,15(7):533 tance Updates,2025,79:101197
[39]SWAIN S M,SHASTRY M,HAMILTON E. Targeting [51]ZHANG P,YANG Y,QIAN K,et al. A novel tumor sup⁃
HER2⁃positive breast cancer:advances and future direc⁃ pressor ZBTB1 regulates tamoxifen resistance and aero⁃
tions[J]. Nat Rev Drug Discov,2023,22(2):101-126 bic glycolysis through suppressing HER2 expression in

