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Neuron damage
KynA
Blood vessel
Kyn
KMO 3⁃HK

mRNA
LAT⁃1 transporter

NMDA receptor
BPF
（+）
BBB 3⁃HK QA
（+） （+） ROS
Leucine
IFN⁃γ Immune cells IL⁃1β，TNF⁃α

Brain

Kyn：kynurenine；KynA：kynurenic acid；KMO：kynurenine⁃3⁃monooxygenase；3⁃HK：3⁃hydroxy⁃kynurenine；BPF：bisphenol F；BBB：blood⁃brain
barrier；LAT⁃1：large neutral amino acid transporter 1；QA：quinolinic acid；ROS:reactive oxygen species；IFN⁃γ：interferon gamma；IL⁃1β：interleukin⁃1β；
TNF⁃α：tumor necrosis factor⁃alpha.
图8 BPF通过3⁃HK引起小鼠抑郁样改变的机制
Figure 8 Mechanism of BPF⁃induced depression⁃like changes in mice through 3⁃HK

Yimin assisted in experiments and participated in article proof⁃ 621：1389-1396
reading and revision；FAN Yunwen and LIU Jianjia were respon⁃ ［7］ MENG Z Y，WANG D Z，LIU W，et al. Perinatal exposure
sible for assisting the experiment；WANG Jun was responsible to Bisphenol S（BPS）promotes obesity development by
for research design and experimental guidance，as well as paper interfering with lipid and glucose metabolism in male
review. mouse offspring［J］. Environ Res，2019，173：189-198

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