Page 43 - 南京医科大学自然版
P. 43
第46卷第7期 李天天,梁晓静,乙红艳,等. 帕金森病患者血浆神经病理性蛋白及炎症因子与便秘的相关性[J].
2026年7月 南京医科大学学报(自然科学版),2026,46(7):983-990 ·989 ·
作者贡献声明: 681-685
李天天负责课题设计、数据收集、数据整理、统计分析、 [9] CARLSEN H,PAJARI A M. Dietary fiber ⁃ a scoping
论文撰写与修改;梁晓静、乙红艳、许富贵负责数据收集、量 review for Nordic nutrition recommendations 2023[J].
表评估、统计分析;王丽君、欧洲负责研究指导、论文指导;佟 Food Nutr Res,2023,67:1-14
强负责课题设计、研究指导、论文修改、经费支持。 [10]QUIGLEY E M M. Constipation in Parkinson’s disease[J].
Author’s Contributions: Semin Neurol,2023,43(4):562-571
LI Tiantian was responsible for study design,data [11]OU Z,ZHOU Y Z,WANG L J,et al. NLRP3 inflamma⁃
collection,data organization,statistical analysis,manuscript some inhibition prevents α⁃synuclein pathology by reliev⁃
writing and revision. LIANG Xiaojing,YI Hongyan,and XU ing autophagy dysfunction in chronic MPTP ⁃ treated
Fugui were responsible for data collection,scale assessment, NLRP3 knockout mice[J]. Mol Neurobiol,2021,58(4):
and statistical analysis. WANG Lijun and OU Zhou were 1303-1311
responsible for study supervision and manuscript guidance. [12]FAN Z,PAN Y T,ZHANG Z Y,et al. Systemic activation
TONG Qiang was responsible for study design, study of NLRP3 inflammasome and plasma α⁃synuclein levels
supervision,manuscript revision,and funding support. are correlated with motor severity and progression in
[参考文献] Parkinson’s disease[J]. J Neuroinflammation,2020,17
(1):11
[1] ARAÚJO B,CARIDADE⁃SILVA R,SOARES⁃GUEDES
[13]HAN Q Q,LE W D. NLRP3 inflammasome⁃mediated neu⁃
C,et al. Neuroinflammation and Parkinson’s disease ⁃
roinflammation and related mitochondrial impairment in
from neurodegeneration to therapeutic opportunities[J].
Parkinson’s disease[J]. Neurosci Bull,2023,39(5):
Cells,2022,11(18):2908
832-844
[2] TANSEY M G,WALLINGS R L,HOUSER M C,et al.
[14]SAAD H M,ATEF E,ELSAYED A E. New insights on
Inflammation and immune dysfunction in Parkinson
the potential role of pyroptosis in Parkinson’s neuropa⁃
disease[J]. Nat Rev Immunol,2022,22(11):657-673
thology and therapeutic targeting of NLRP3 inflamma⁃
[3] DEVOS D,LEBOUVIER T,LARDEUX B,et al. Colonic
some with recent advances in nanoparticle⁃based miRNA
inflammation in Parkinson’s disease[J]. Neurobiol Dis,
therapeutics[J]. Mol Neurobiol,2025,62(7):9365-9384
2013,50:42-48
[15]GLEESON T A,KAISER C,LAWRENCE C B,et al. The
[4] 李 奇,秦亚娟,唐立钧. 帕金森病标志物α⁃突触核蛋
NLRP3 inflammasome is essential for IL⁃18 production in
白聚集抑制剂的研究进展[J]. 南京医科大学学报(自
a murine model of macrophage activation syndrome[J].
然科学版),2025,45(3):404-417
Dis Model Mech,2024,17(7):dmm050762
LI Q,QIN Y J,TANG L J. Research progress on inhibitors
[16]KAMINSKY L W,AL⁃SADI R,MA T Y. IL⁃1β and the in⁃
of α ⁃ synuclein aggregation,a marker for Parkinson’s
testinal epithelial tight junction barrier[J]. Front Immu⁃
disease[J]. Journal of Nanjing Medical University(Natural
nol,2021,12:767456
Sciences),2025,45(3):404-417
[17]DOCSA T,SIPOS A,COX C S,et al. The role of inflamma⁃
[5] DMAGALHÃES J,CANDEIAS E,MELO⁃MARQUES I,
tory mediators in the development of gastrointestinal mo⁃
et al. Intestinal infection triggers mitochondria⁃mediated
tility disorders[J]. Int J Mol Sci,2022,23(13):6917
α⁃synuclein pathology:relevance to Parkinson’s disease[J].
[18]DZAMKO N. Cytokine activity in Parkinson’s disease[J].
Cell Mol Life Sci,2023,80(6):166
Neuronal Signal,2023,7(4):NS20220063
[6] HOUSER M C,CAUDLE W M,CHANG J J,et al.
[19]SHEN X N,HUANG S Y,CUI M,et al. Plasma glial fibril⁃
Experimental colitis promotes sustained,sex⁃dependent, lary acidic protein in the Alzheimer disease continuum:
T ⁃ cell ⁃ associated neuroinflammation and Parkinsonian relationship to other biomarkers,differential diagnosis,
neuropathology[J]. Acta Neuropathol Commun,2021,9 and prediction of clinical progression[J]. Clin Chem,
(1):139
2023,69(4):411-421
[7] MOKHTARE M,ALIMORADZADEH R,AGAH S,et al.
[20]CHE N N,OU R W,LI C Y,et al. Plasma GFAP as a prog⁃
The association between modulating inflammatory
nostic biomarker of motor subtype in early Parkinson’s
cytokines and constipation of geriatrics in Iran[J].
disease[J]. NPJ Parkinsons Dis,2024,10(1):48
Middle East J Dig Dis,2017,9(4):228-234 [21]乙红艳,梁晓静,许富贵,等. 血浆胶质纤维酸性蛋白、
[8] AGACHAN F,CHEN T,PFEIFER J,et al. A constipation α⁃突触核蛋白水平与帕金森病病情进展的相关性[J].
scoring system to simplify evaluation and management of 中华行为医学与脑科学杂志,2023,32(11):999-1004
constipated patients[J]. Dis Colon Rectum,1996,39(6): YI H Y,LIANG X J,XU F G,et al. Correlation between

