Page 17 - 南京医科大学学报自然科学版
P. 17

第41卷第3期         刘   雪,马春梅,王冰微,等. 炎症小体AIM2在小鼠肥胖发生过程中的作用和机制研究[J].
                  2021年3月                     南京医科大学学报(自然科学版),2021,41(03):317-323                       ·323 ·


                    233(9):6425-6440                                   neuroplasticity and spatial memory of mice[J]. Brain Res
               [5] ZHOU D,HUANG C,LIN Z,et al. Macrophage polariza⁃    Bull,2019,152(1):85-94
                    tion and function with emphasis on the evolving roles of  [13]DANG E V,MCDONALD J G,RUSSELL D W,et al. Oxy⁃
                    coordinated regulation of cellular signaling pathways[J].  sterol restraint of cholesterol synthesis prevents AIM2 in⁃
                    Cell Signal,2014,26(2):192-197                     flammasome activation[J]. Cell,2017,171(5):1057-
               [6] ODEGAARD J I,CHAWLA A. The immune system as a       1071.e11
                    sensor of the metabolic state[J]. Immunity,2013,38(4):  [14] GHORPADE D S,OZCAN L,ZHENG Z,et al. Hepatocyte
                    644-654                                            ⁃secreted DPP4 in obesity promotes adipose inflammation
               [7] KEIRAN N,CEPERUELO⁃MALLAFRE V,CALVO E,et            and insulin resistance[J]. Nature,2018,555(7698):673
                    al. SUCNR1 controls an anti ⁃ inflammatory program in  [15] HILL D A,LIM H W,KIM Y H,et al. Distinct macro⁃
                    macrophages to regulate the metabolic response to obesity  phage populations direct inflammatory versus physiologi⁃
                    [J]. Nat Immunol,2019,20(5):581-592                cal changes in adipose tissue[J]. Proc Natl Acad Sci U S
               [8] BROZ P,DIXIT V M. Inflammasomes:mechanism of as⁃    A,2018,115(22):E5096-E5105
                    sembly,regulation and signalling[J]. Nat Rev Immunol,  [16] RUSSO L,LUMENG C N. Properties and functions of adi⁃
                    2016,16(7):407-420                                 pose tissue macrophages in obesity[J]. Immunology,
               [9] TRUAX A D,CHEN L,TAM J W,et al. The inhibitory in⁃  2018,155(4):407-417
                    nate immune sensor NLRP12 maintains a threshold  [17] NAIK S,LARSEN S B,GOMEZ N C,et al. Inflammatory
                    against obesity by regulating gut microbiota homeostasis  memory sensitizes skin epithelial stem cells to tissue dama⁃
                    [J]. Cell Host Microbe,2018,24(3):364-378          ge[J]. Nature,2017,550(7677):475-480
               [10] MURPHY A J,KRAAKMAN M J,KAMMOUN H L,et al.   [18] WILSON J E,PETRUCELLI A S,CHEN L,et al. Inflam⁃
                    IL ⁃ 18 production from the NLRP1 inflammasome pre⁃  masome⁃independent role of AIM2 in suppressing colon
                    vents obesity and metabolic syndrome[J]. Cell Metab,  tumorigenesis via DNA⁃PK and Akt[J]. Nat Med,2015,
                    2016,23(1):155-164                                 21(8):906-913
               [11]CATANO Y G,CANIZALES E E,URESTI RIVERA R E,   [19] ROBBLEE M M,KIM C C,PORTER A J,et al. Saturated
                    et al. Increased levels of AIM2 and circulating mitochon⁃  fatty acids engage an IRE1α⁃dependent pathway to acti⁃
                    drial DNA in type 2 diabetes[J]. Iran J Immunol,2018,  vate the NLRP3 inflammasome in myeloid cells[J]. Cell
                    15(2):142-155                                      Rep,2016,14(11):2611-2623
               [12] CHEN J,SHU S,CHEN Y,et al. AIM2 deletion promotes                       [收稿日期] 2020-04-21
   12   13   14   15   16   17   18   19   20   21   22