Page 12 - 南京医科大学学报自然科学版
P. 12

第41卷第7期
               ·942 ·                            南 京    医 科 大 学 学         报                        2021年7月


             [2] MAYR C. Regulation by 3′⁃untranslated regions[J]. An⁃  UTRs[J]. Trends Cell Biol,2016,26(3):227-237
                   nu Rev Genet,2017,51:171-194                 [16] HUTVÁGNER G,ZAMORE P D. A microRNA in a multi⁃
             [3] MAYR C. What are 3′UTRs doing?[J]. Cold Spring Harb  ple⁃turnover RNAi enzyme complex[J]. Science,2002,
                   Perspect Biol,2019,11(10):a034728                 297(5589):2056-2060
             [4] BERKOVITS B D,MAYR C. Alternative 3′UTRs act as  [17] HAMMOND S M,BERNSTEIN E,BEACH D,et al. An
                   scaffolds to regulate membrane protein localization[J].  RNA ⁃ directed nuclease mediates post ⁃ transcriptional
                   Nature,2015,522(7556):363-367                     gene silencing in Drosophila cells[J]. Nature,2000,404
             [5] KOPP E,MEDZHITOV R,CAROTHERS J,et al. ECSIT        (6775):293-296
                   is an evolutionarily conserved intermediate in the Toll/IL⁃  [18] RYTHER R C,FLYNT A S,PHILLIPS J A,et al. siRNA
                   1 signal transduction pathway[J]. Genes Dev,1999,13  therapeutics:big potential from small RNAs[J]. Gene
                  (16):2059-2071                                     Ther,2005,12(1):5-11
             [6] XIAO C,SHIM J H,KLÜPPEL M,et al. Ecsit is required  [19] NAIR J K,WILLOUGHBY J L,CHAN A,et al. Multiva⁃
                   for Bmp signaling and mesoderm formation during mouse  lent N ⁃ acetylgalactosamine ⁃ conjugated siRNA localizes
                   embryogenesis[J]. Genes Dev,2003,17(23):2933-2949  in hepatocytes and elicits robust RNAi⁃mediated gene si⁃
             [7] VOGEL R O,JANSSEN R J,VAN DEN BRAND M A,et          lencing[J]. J Am Chem Soc,2014,136(49):16958-
                   al. Cytosolic signaling protein ECSIT also localizes to mi⁃  16961
                   tochondria where it interacts with chaperone NDUFAF1  [20] WI S M,MOON G,KIM J,et al. TAK1⁃ECSIT⁃TRAF6
                   and functions in complex I assembly[J]. Genes Dev,  complex plays a key role in the TLR4 signal to activate NF
                   2007,21(5):615-624                                ⁃κB[J]. J Biol Chem,2014,289(51):35205-35214
             [8] BARTEL D P. Metazoan microRNAs[J]. Cell,2018,173  [21]WEST A P,BRODSKY I E,RAHNER C,et al. TLR sig⁃
                  (1):20-51                                          nalling  augments  macrophage  bactericidal  activity
             [9] SØRENSEN A E,WISSING M L,SALÖ S,et al. MicroR⁃      through mitochondrial ROS [J]. Nature,2011,472
                   NAs related to polycystic ovary syndrome(PCOS)[J].  (7344):476-480
                   Genes(Basel),2014,5(3):684-708               [22] CARNEIRO F R,LEPELLEY A,SEELEY J J,et al. An
             [10] SILLIVAN S E,JAMIESON S,DE NIJS L,et al. MicroR⁃   essential role for ECSIT in mitochondrial complex I as⁃
                   NA regulation of persistent stress⁃enhanced memory[J].  sembly and mitophagy in macrophages[J]. Cell Rep,
                   2020,25(5):965-976                                2018,22(10):2654-2666
             [11] EULALIO A,HUNTZINGER E,NISHIHARA T,et al.     [23] TIMMERS L,SLUIJTER J P,VAN KEULEN J K,et al.
                   Deadenylation is a widespread effect of miRNA regulation  Toll⁃like receptor 4 mediates maladaptive left ventricular
                  [J]. RNA,2009,15(1):21-32                          remodeling and impairs cardiac function after myocardial
             [12] DONG Y,SIEGWART D J,ANDERSON D G. Strategies,      infarction[J]. Circ Res,2008,102(2):257-264
                   design,and chemistry in siRNA delivery systems[J]. Adv  [24] DEBERGE M,SHAH S J,WILSBACHER L,et al. Macro⁃
                   Drug Deliv Rev,2019,144:133-147                   phages in heart failure with reduced versus preserved
             [13] CROOKE S T,WITZTUM J L,BENNETT C F,et al. RNA      ejection fraction[J]. Trends Mol Med,2019,25(4):328-
                   ⁃targeted therapeutics[J]. Cell Metab,2018,27(4):714-  340
                   739                                          [25] LI Y,CHEN B,YANG X,et al. S100a8/a9 signaling
             [14] TIAN B,MANLEY J L. Alternative polyadenylation of  causes mitochondrial dysfunction and cardiomyocyte
                   mRNA precursors[J]. Nat Rev Mol Cell Biol,2017,18  death in response to ischemic/reperfusion injury[J]. Cir⁃
                  (1):18-30                                          culation,2019,140(9):751-764
             [15] MAYR C. Evolution and biological roles of alternative 3′                [收稿日期] 2021-04-30
   7   8   9   10   11   12   13   14   15   16   17