Page 73 - 南京医科大学学报自然科学版

第42卷第11期 南京医科大学学报（自然科学版）
2022年11月 Journal of Nanjing Medical University（Natural Sciences） ·1565 ·

·临床研究·

无症状高尿酸血症患者凝血功能相关指标分析

丁红梅 ，张 铮 ，杨淑娴 ，顾 敏 1，2*
1，2
1，2
1，2
南京医科大学第一附属医院检验学部，国家医学检验临床医学研究中心分中心，江苏 南京 210029
1 2

［摘 要］ 目的：探讨无症状高尿酸血症患者凝血功能相关指标的变化，及随着血清尿酸（serum uric acid，SUA）水平增高，
SUA与凝血功能的关系。方法：收集2018年1月—2021年9月于南京医科大学第一附属医院健康管理中心进行健康体检的人
群共2 389例，其中男1 497例，女892例。由于男性、女性SUA水平的差异，故分开讨论。比较无症状高尿酸血症患者凝血功
能相关指标［凝血酶原时间（prothrombin time，PT）、活化部分凝血活酶时间（activated partial thromboplastin time，APTT）、纤维蛋
白原（fibrinogen，FIB）、凝血酶时间（thrombin time，TT）、D⁃二聚体（D⁃dimer，DD）和血小板（platelet，PLT）］。根据SUA四分位水
平将男性、女性各分为4组，分析随着SUA水平的增高，凝血功能相关指标的变化，以及SUA与凝血功能相关指标的相关性。
结果：男性无症状高尿酸血症患病率明显高于女性（P＜0.001）。男性、女性无症状高尿酸血症患者血浆PT缩短，血浆FIB、全
血 PLT 水平上升（P 均＜0.05）。随着 SUA 水平的升高，男性不同组别间血浆 PT、FIB、全血 PLT 差异有统计学意义（P 均＜
0.05），女性不同组别间血浆PT差异有统计学意义（P＜0.05）。男性SUA水平与血浆PT、DD呈负相关，与血浆FIB、全血PLT水
平呈正相关（均P＜0.05），女性SUA水平与血浆PT呈负相关，与血浆FIB、TT呈正相关（P均＜0.05）。结论：血清高尿酸水平可
增加血浆黏度，活化血小板，影响外源性凝血功能，临床诊治中对无症状高尿酸血症应正确认识和及时干预，建议按时常规体
检，为早期预防凝血功能异常性疾病提供有效保障。
［关键词］ 无症状高尿酸血症；血清尿酸；凝血功能
［中图分类号］ R589.7 ［文献标志码］ A ［文章编号］ 1007⁃4368（2022）11⁃1565⁃07
doi：10.7655/NYDXBNS20221110

Analysis of coagulation function correlative indexes in asymptomatic hyperuricemia patients
1，2 1，2 1，2 1，2*
DING Hongmei ，ZHANG Zheng ，YANG Shuxian ，GU Min
Department of Laboratory Medicine，Branch of National Clinical Research Center for Laboratory Medicine，the First
1 2
Affiliated Hospital of Nanjing Medical University，Nanjing 210029，China

［Abstract］ Objective：This study aims to observe the changes of coagulation indexes in patients with asymptomatic hyperuricemia，
and analyze its correlation with the increasing serum uric acid（SUA）level. Methods：Data were collected from 2 389 patients who
have taken physical examinations in the Health Management Center of the First Affiliated Hospital of Nanjing Medical University from
January 2018 to September 2021，including 1 497 males and 892 females. Due to the difference in SUA levels between males and
females，they were discussed separately. The following coagulation indexes of patients with asymptomatic hyperuricemia were analyzed：
prothrombin time（PT），activated partial thromboplastin time（APTT），fibrinogen（FIB），thrombin time（TT），D⁃dimer（DD）and platelet
（PLT）. The data of males and females were separately divided into four groups according to the SUA quartile level. With the increase
of the SUA level，the changes of coagulation indexes and its correlation with SUA were analyzed. Results：The prevalence of
asymptomatic hyperuricemia was significantly higher in males than that in females（P＜0.001）. Both in male and female asymptomatic
hyperuricemia patients，data displayed shortened plasma PT（P＜0.05），while the levels of FIB and PLT increased（P＜0.05）. With the
increase of SUA level，there were statistically significant differences in PT，FIB and PLT among different groups in males（P＜0.05），
and there existed statistically significant differences in plasma PT among different female groups（P＜0.05）. The SUA level of male
patients was negatively correlated with PT nor DD，and positively correlated with FIB and PLT（P＜0.05）. The SUA level of female
patients was negatively correlated with PT，and positively correlated with FIB and TT（P＜0.05）. Conclusion：The high SUA levels can

［基金项目］ 江苏省“科教强卫”实验诊断学重点实验室项目（ZDXKB2016005）
∗
通信作者（Corresponding author），E⁃mail：18851721609@163.com