Page 43 - 南京医科大学学报自然科学版

第42卷第2期 南京医科大学学报（自然科学版）
2022年2月 Journal of Nanjing Medical University（Natural Sciences） ·189 ·

·临床医学·

肿瘤相关巨噬细胞亚型在子宫内膜癌中的表达和意义

葛素梅 ，强 贤 ，程羽青 ，欧阳俊 ，刘孟璐 1
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南京医科大学附属常州市妇幼保健院病理科，江苏 常州 213003；南京医科大学附属常州市第二人民医院病理科，江苏
1 2
常州 213003

［摘 要］ 目的：探讨肿瘤相关巨噬细胞（tumor associated macrophage，TAM）标志物CD163和CD68蛋白在子宫内膜癌中的表
达，分析其与子宫内膜癌患者临床病理特征及5年总生存率的相关性。方法：收集2010年1月—2015年12月在南京医科大学
附属常州市妇幼保健院院就诊的46例子宫内膜癌患者作为观察组，并以同期就诊的25例正常增生期子宫内膜患者作为对照
组，采用免疫组织化学法检测两组患者的 CD163、CD68 的表达水平，以 TAM 计数的中位数为界，将子宫内膜癌病例分为
CD163、CD68 高表达组和低表达组，将 CD163/CD68 比值以中位数为界分为 CD163/CD68 高比值组和低比值组，分析 CD163、
CD68 的表达水平和 CD163/CD68 比值与子宫内膜癌患者临床病理参数及其预后的关系。结果：子宫内膜癌组织中 CD163、
CD68的表达水平均显著高于正常增生期子宫内膜患者（P < 0.05）。CD163表达水平与病理分级、有无淋巴结转移和FIGO分
期显著相关（P < 0.05），CD68表达水平与肌层浸润深度和FIGO分期显著相关（P < 0.05），CD163/CD68比值的高低与年龄、病
理学分级、淋巴结转移和FIGO分期显著相关（P < 0.05），CD163、CD68的表达及CD163/CD68比值与患者生存率无显著相关性
（P > 0.05），而淋巴结转移与患者的预后相关。结论：TAM可能参与子宫内膜癌的发生发展，CD163和CD68的表达可能在子宫
内膜癌的进展中起到重要作用。
［关键词］ 子宫内膜癌；肿瘤相关巨噬细胞；CD163；CD68
［中图分类号］ R737.33 ［文献标志码］ A ［文章编号］ 1007⁃4368（2022）02⁃189⁃06
doi：10.7655/NYDXBNS20220207

Expression and significance of tumor associated macrophages subtypes in endometrial
cancer

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GE Sumei ，QIANG Xian ，CHENG Yuqing ，OUYANG Jun ，LIU Menglu 1
1 Department of Pathology，Changzhou Maternal and Child Health Care Hospital Affiliated to Nanjing Medical
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University，Changzhou 213003；Department of Pathology，Changzhou No.2 People’s Hospital Affiliated to Nanjing
Medical University，Changzhou 213003，China
［Abstract］ Objective：This study aims to investigate the expression of CD163，CD68 in endometrial cancer（EC）and its relation with
the clinicopathological features and overall survival rate. Methods：A total of 46 EC tumors were collected from January 2010 to
December 2015 in Changzhou Maternal and Child Health Care hospital affiliated to Nanjing Medical University as the experimental
group，while contemporaneous 25 cases with benign endometrial diagnosed were selected as the control group. Immunhistochemistry
was applied to detect the expressions of CD68 and CD163 in the two groups. Taking the median expression level of tumor⁃associated
macrophage（TAM）as the cut⁃off value，experimental group was divided into high expression group and low expression group of CD68
or CD163. The median ratio of CD163/CD68 was also taken as the cut⁃off value for CD163/CD68 high ratio group and low ratio group.
The relationship of their expressions and clinicopathological features and prognosis of endometrial cancer were analyzed. Results：The
expression of CD163 and CD68 in EC was significantly higher than that in control group. The expression of CD163 was associated with
high pathological grade，high FIGO stage，lymph node metastasis. The expression of CD68 was associated with myometrial invasion，
high FIGO stage. The ratio of CD163/CD68 was associated with high pathological grade，high FIGO stage，lymph node metastasis.
Survival analysis found that there was no sigfnificant statistical difference in 5 year overall survival rate between the patients with the

［基金项目］ 常州市卫健委青年项目（QN2019035）；常州市海外人才专项（CQ20204036）
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通信作者（Corresponding author），E⁃mail：109332820 @qq.com