Page 41 - 南京医科大学学报自然科学版

第42卷第4期 南京医科大学学报（自然科学版）
2022年4月 Journal of Nanjing Medical University（Natural Sciences） ·491 ·

·临床研究·

老年冠心病患者生存影响因素分析

刘 欢，张晓宇，王向明，卢 妙，查志敏，闵笑颜，庞斯斯，李秋爽，郭 妍 *
南京医科大学第一附属医院老年心血管科，江苏 南京 210029

［摘 要］ 目的：分析老年冠心病患者生存的影响因素。方法：收集140例老年冠心病患者的相关资料，平均随访3.5年。探
讨患者发生主要不良心脑血管事件（major adverse cardiac and cerebral events，MACCE）的影响因素，进一步分析各影响因素对
MACCE的预测价值。结果：根据MACCE组与无MACCE组临床资料比较、Cox回归分析及Kaplan⁃Meier曲线分析结果，尿素氮
（blood urea nitrogen，BUN）、总胆固醇（total cholesterol，TC）、左房内径（left atrial diameter，LAD）、心脏瓣膜钙化（cardiac valve
calcification，CVC）是老年冠心病患者发生MACCE的相关影响因素。未发现1,25羟维生素D3水平与MACCE的发生相关。受
试者工作特征（receiver operating characteristic，ROC）曲线显示，联合 BUN、TC、LAD、CVC 预测 MACCE 的价值最大。结论：
BUN、TC、LAD、CVC是老年冠心病患者发生MACCE的重要影响因素，而未发现1，25羟维生素D3水平与MACCE的发生相关。
［关键词］ 老年人；冠心病；主要不良心脑血管事件；预后
［中图分类号］ R541.4 ［文献标志码］ A ［文章编号］ 1007⁃4368（2022）04⁃491⁃07
doi：10.7655/NYDXBNS20220405

Analysis of factors influencing the survival of elderly patients with coronary heart disease
LIU Huan，ZHANG Xiaoyu，WANG Xiangming，LU Miao，ZHA Zhimin，MIN Xiaoyan，PANG Sisi，LI Qiushuang，

GUO Yan *
Department of Geriatric Cardiology，the First Affiliated Hospital of Nanjing Medical University，Nanjing 210029，China

［Abstract］ Objective：To observe and analyze the factors affecting the survival of elderly patients with coronary heart disease.
Methods：Data of 140 elderly patients with coronary heart disease were collected and patients were followed up for an average of 3.5
years. The influencing factors of major adverse cardiac and cerebral events（MACCE）in patients were investigated，and the predictive
value of each influencing factor for MACCE was further analyzed. Results：According to the comparison of clinical data between the
MACCE group and the non ⁃ MACCE group，Cox regression analysis and Kaplan ⁃ Meier curve，blood urea nitrogen（BUN），total
cholesterol（TC），left atrial diameter（LAD），and cardiac valve calcification（CVC）were associated with the development of MACCE in
elderly patients with coronary heart disease. There was no correlation between 1，25 hydroxyvitamin D3 level and the occurrence of
MACCE. According to the results of receiver operating characteristic（ROC）curve，the combination of BUN，TC，LAD and CVC had
the greatest value in predicting MACCE. Conclusion：In this study，BUN，TC，LAD and CVC are found to be important influencing
factors for the occurrence of MACCE in elderly patients with coronary heart disease，while there is no correlation between the level of
25 hydroxyvitamin D and the occurrence of MACCE.
［Key words］ elderly people；coronary heart disease；major adverse cardiac and cerebral event；prognosis
［J Nanjing Med Univ，2022，42（04）：491⁃497］

随着我国人口老龄化趋势日益显现，老年人群
的基数不断增加。冠心病是我国老年人的常见病
和多发病，该病具有较高的发病率和病死率，影响
［基金项目］ 江苏省干部保健科研课题（BJ18017, BJ19016）
∗ 我国居民的寿命。老年冠心病患者常合并共病，因
通信作者（Corresponding author），E⁃mail：guoyan51@hotmail.
com 此影响其发生主要不良心脑血管事件（major adverse