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南京医科大学学报(自然科学版)                                  第42卷第5期
               ·708 ·                     Journal of Nanjing Medical University(Natural Sciences)   2022年5月


             ·临床研究·

              24 节段二维斑点追踪技术评估妊娠期糖尿病胎儿心室收缩功

              能的研究



              房   宁 ,陈丽娟 ,范光磊 ,李晓琴           1
                     1
                             1
                                     2
               南京医科大学附属常州第二人民医院超声科,核医学科,江苏                      常州 213000
              1                                   2

             [摘    要] 目的:运用24节段二维斑点追踪(2D⁃STI)技术评估妊娠期糖尿病(GDM)胎儿的心室收缩功能。方法:收集2020年
              5月—2021年8月在南京医科大学附属常州第二人民医院就诊的孕晚期单胎妊娠孕妇111例,按口服葡萄糖耐量试验(OGTT)
              结果分为GDM组与正常对照组。所有孕妇均行胎儿超声心动图检查,获取常规胎儿超声心动图评估指标,包括左室射血分数
             (LVEF)、左室心输出量(LVCO)、面积变化分数(FAC)、心脏球形指数(GSI)、二尖瓣环平面收缩期位移(MAPSE)、三尖瓣环平
              面收缩期位移(TAPSE)。同时使用24节段2D⁃STI技术获取胎儿心室应变指标:左室整体纵向应变(LVGLS)、左室整体圆周应
              变(LVGCS)、右室整体纵向应变(RVGLS)、右室游离壁应变(RVFWSt)。结果:GDM组与正常对照组胎儿间常规超声心动图评
              估指标、LVGLS 比较差异无统计学意义(P>0.05);GDM 组胎儿 LVGCS、RVGLS、RVFWSt 明显低于正常对照组(P<0.05);
              LVGLS 与 LVEF、LVFAC 具有正相关性(r=0.544、0.714,P<0.05),LVGCS 与 LVEF、LVFAC、MAPSE 具有正相关性(r=0.837、
              0.751、0.191,P<0.05),RVGLS、RVFWSt 均与 RVFAC 具有正相关性(r=0.517、0.421,P<0.05);孕妇体重指数(BMI)是 RVGLS
              的独立预测因子(β=0.496,95%CI:0.147~0.846,P<0.05)。结论:GDM会引起胎儿心室收缩功能下降,24节段2D⁃STI技术可及
              时、准确地监测胎儿心室收缩功能,有利于临床妊娠监控。
             [关键词] 24节段二维斑点追踪技术;右心室应变:妊娠期糖尿病;胎儿超声心动图
             [中图分类号] R445.1                   [文献标志码] A                        [文章编号] 1007⁃4368(2022)05⁃708⁃07
              doi:10.7655/NYDXBNS20220517


              Evaluation of fetal ventricular systolic function in gestational diabetes mellitus by using 24⁃
              segment two⁃dimensional speckle tracking imaging technique

                        1            1            2          1
              FANG Ning ,CHEN Lijuan ,FAN Guanglei ,LI Xiaoqin
                                     2
              1 Department of Ultrasound,Department of Nuclear Medicine,Changzhou No.2 People’s Hospital of Nanjing Medical
              University,Changzhou 213000,China


             [Abstract] Objective:To evaluate the ventricular systolic function of fetuses with gestational diabetes mellitus(GDM)by using 24⁃
              segment two ⁃ dimensional speckle tracking imaging(2D ⁃ STI)technique. Methods:A total of 111 singleton pregnant women in
              Changzhou second people’s Hospital affiliated to Nanjing Medical University from May 2020 to August 2021 were collected and
              divided into GDM group and normal control group according to the results of oral glucose tolerance test(OGTT). All pregnant women
              underwent fetal echocardiography to obtain routine fetal echocardiographic evaluation indexes,including left ventricular ejection
              fraction(LVEF),left ventricular cardiac output(LVCO),area change fraction(FAC),cardiac globular sphericity index(GSI),mitral
              annulus plane systolic displacement(MAPSE),tricuspid annulus plane systolic displacement(TAPSE). At the same time,24⁃segment
              2D ⁃ STI technique was used to obtain fetal ventricular strain indexes:left ventricular global longitudinal strain(LVGLS),left
              ventricular global circumferential strain(LVGCS),right ventricular global longitudinal strain(RVGLS),right ventricular free wall
              strain(RVFWSt). Results:There was no significant difference in traditional echocardiographic evaluation indexes and LVGLS between
              the GDM group and the normal control group,but the fetal LVGCS,RVGLS and RVFWSt in the GDM group were significantly lower
              than those in the normal control group(P<0.05). There were positive correlations between LVGLS and LVEF,LVFAC(r=0.544,
              0.714,P<0.05),between LVGCS and LVEF,LVFAC,MAPSE(r=0.837,0.751,0.191,P<0.05),and between RVGLS,RVFWSt and
              RVFAC(r=0.517,0.421,P<0.05). Maternal body mass index(BMI)was an independent predictor of RVGLS(β =0.496,95% CI:
              0.147~0.846,P<0.05). Conclusion:GDM can cause the decrease of fetal ventricular systolic function. 24⁃segment 2D⁃STI technique
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