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第42卷第5期 郑礼平,王玉婷,倪罗番,等. 兼具抗氧化和γ⁃氨基丁酸增强活性的多功能抗脑卒中化合物[J].
2022年5月 南京医科大学学报(自然科学版),2022,42(05):644-649 ·649 ·
活性,让化合物的活性比较更为直观。 [10] STUMPFE D,HOCH A,BAJORATH J. Introducing the
metacore concept for multi⁃target ligand design[J]. RSC
[参考文献]
Med Chem,2021,12(4):628-635
[1] PAUL S,CANDELARIO⁃JALIL E. Emerging neuroprotec⁃
[11] ZHOU L,LI F,XU H B,et al. Treatment of cerebral isch⁃
tive strategies for the treatment of ischemic stroke:An
emia by disrupting ischemia⁃induced interaction of nNOS
overview of clinical and preclinical studies[J]. Exp Neu⁃
with PSD⁃95[J]. Nat Med,2010,16(12):1439-1443
rol,2021,335:113518
[12] XU J,WANG Y,WANG A,et al. Safety and efficacy of
[2] WATANABE K,TANAKA M,YUKI S,et al. How is edar⁃
Edaravone Dexborneol versus edaravone for patients with
avone effective against acute ischemic stroke and amyo⁃
acute ischaemic stroke:a phase II,multicentre,ran⁃
trophic lateral sclerosis?[J]. J Clin BiochemNutr,2018,
domised,double⁃blind,multiple⁃dose,active⁃controlled
62(1):20-38
clinical trial[J]. Stroke Vasc Neurol,2019,4(3):109-
[3] SHEFNER J,HEIMAN⁃PATTERSON T,PIORO E P,et
114
al. Long ⁃ term edaravone efficacy in amyotrophic lateral [13] 陈佳佳,刘金春,常 磊,等. 冰片及其类似物对谷氨酸
sclerosis:post⁃hoc analyses of Study 19(MCI186⁃19)[J]. 诱导神经元细胞损伤的保护作用[J]. 南京医科大学学
Muscle Nerve,2020,61(2):218-221
报(自然科学版),2013,33(5):630-635
[4] 曹媛媛,丁 可,胡 静,等. 快充式经鼻湿化高流量通
[14] POLKAM N,RAMASWAMY V R,RAYAM P,et al. Syn⁃
气在静脉麻醉下宫腔镜手术中的应用效果[J]. 南京医
thesis,molecular properties prediction and anticancer,an⁃
科大学学报(自然科学版),2021,41(10):1517-1520
tioxidant evaluation of new edaravone derivatives[J].
[5] GOENKA L,UPPUGUNDURI SATYANARAYANA C R.
Bioorg Med Chem Lett,2016,26(10):2562-2568
Neuroprotective agents in acute ischemic stroke⁃A reality
[15] KRASOWSKI M D,JENKINS A,FLOOD P,et al. Gener⁃
check[J]. Biomed Pharmacother,2019,109:2539-2547
al anesthetic potencies of a series of propofol analogs cor⁃
[6] WU Q J,TYMIANSKI M. Targeting nmda receptors in
relate with potency for potentiation of gamma⁃aminobutyr⁃
stroke:new hope in neuroprotection[J]. Mol Brain,2018,
ic acid(GABA)current at the GABA(A)receptor but not
11(1):15
with lipid solubility[J]. J Pharmacol Exp Ther,2001,297
[7] AMANTEA D,BAGETTA G. Excitatory and inhibitory
(1):338-351
amino acid neurotransmitters in stroke:from neurotoxicity
[16] TRAPANI G,LATROFA A,FRANCO M,et al. Propofol
to ischemic tolerance[J]. Curr Opin Pharmacol,2017,
analogues. synthesis,relationships between structure and
35:111-119
affinity at GABAA receptor in rat brain,and differential
[8] 陈 伟,赵 麟,刘 宁,等. 星形胶质细胞来源的
electrophysiological profile at recombinant human GAB⁃
GJA1⁃20k 在氧化应激后参与神经元保护作用的机制
AA receptors[J]. J Med Chem,1998,41(11):1846-1854
[J]. 南京医科大学学报(自然科学版),2020,40(8):
[17] QIN L,REN L,WAN S,et al. Design,synthesis,and eval⁃
1098-1104
uation of novel 2,6 ⁃ disubstituted phenol derivatives as
[9] YANG C Y,LIU S Y,WANG H Y,et al. Neuroprotection
general anesthetics[J]. J Med Chem,2017,60(9):3606-
by propofol post⁃conditioning:focus on PKMζ/KCC2 path⁃
3617
way activity[J]. Cell Mol Neurobiol,2018,38(3):691-
[收稿日期] 2022-02-27
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