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e0166901 ［44］ KEIICHIRO S，BOB M，YASUKO D，et al. Aberrant ex⁃
［32］ XIAO X，PUTATUNDA R，ZHANG Y G，et al. Lympho⁃ pansion of segmented filamentous bacteria in IgA ⁃ defi⁃
toxin β receptor⁃mediated NFκB signaling promotes glial cient gut［J］. Proc Natl Acad Sci U S A，2004，101（7）：
lineage differentiation and inhibits neuronal lineage dif⁃ 1981-1986
ferentiation in mouse brain neural stem/progenitor cells ［45］ GRANDOCH M，FELDMANN K，GÖTHERT J R，et al.
［J］. J Neuroinflammation，2018，15（1）：49 Deficiency in lymphotoxin β receptor protects from ath⁃
［33］ RIFFELMACHER T，GILES D A，ZAHNER S，et al. Met⁃ erosclerosis in apoE⁃deficient mice［J］. Circ Res，2015，
abolic activation and colitis pathogenesis is prevented by 116（8）：e57-e68
lymphotoxin β receptor expression in neutrophils［J］. Mu⁃ ［46］ HU D，MOHANTA S K，YIN C J，et al. Artery tertiary
cosal Immunol，2021，14（3）：679-690 lymphoid organs control aorta immunity and protect
［34］ GALAL G，TAMMAM H，ABDEL AAL A，et al. Role of against atherosclerosis via vascular smooth muscle cell
lymphotoxin⁃α gene polymorphism in hepatitis C virus⁃re⁃ lymphotoxin β receptors［J］. Immunity，2015，42（6）：
lated chronic liver disorders［J］. Infect Drug Resist， 1100-1115
2021，14：1921-1930 ［47］ GUBERNATOROVA E O，POLINOVA A I，PETROPAV⁃
［35］ SELEZNIK G，SEEGER H，BAUER J，et al. The lympho⁃ LOVSKIY M M，et al. Dual role of TNF and LTα in carci⁃
toxin β receptor is a potential therapeutic target in renal nogenesis as implicated by studies in mice［J］. Cancers
inflammation［J］. Kidney Int，2016，89（1）：113-126 （Basel）. 2021，13（8）：1775
［36］ HANS L. Pathogenic mechanisms associated with differ⁃ ［48］ TANIGUCHI K，KARIN M. NF⁃κB，inflammation，immu⁃
ent clinical courses of multiple sclerosis［J］. Front Immu⁃ nity and cancer：coming of age［J］. Nat Rev Immunol，
nol，2018，9：3116 2018，18（5）：309-324
［37］ CREUS K K，DE PAEPE B，WEIS J，et al. The multifaceted ［49］ ZHOU P H，FANG X F，MCNALLY B A，et al. Targeting
character of lymphotoxin β in inflammatory myopathies lymphotoxin⁃mediated negative selection to prevent pros⁃
and muscular dystrophies［J］. Neuromuscul Disord，2012， tate cancer in mice with genetic predisposition［J］. Proc

22（8）：712-719 Natl Acad Sci U S A，2009，106（40）：17134-17139
［38］ Friedrich S K，LANG P A，FRIEBUS⁃KARDASH J，et al. ［50］ TANG H D，WANG Y，CHLEWICKI L K，et al. Facilitat⁃
Mechanisms of lymphatic system⁃specific viral replication ing T cell infiltration in tumor microenvironment over⁃
and its potential role in autoimmune disease［J］. Clin Exp comes resistance to PD ⁃ L1 blockade［J］. Cancer Cell，
Immunol，2019，195（1）：64-73 2016，29（3）：285-296
［39］ ZHU Q Q，LI N，LI F，et al. Association of LTBR polymor⁃ ［51］ AOYAMA S，NAKAGAWA R，NEMOTO S，et al. Check⁃
phisms with chronic hepatitis B virus infection and hepati⁃ point blockade accelerates a novel switch from an NKT⁃
tis B virus⁃related hepatocellular carcinoma［J］. Int Immu⁃ driven TNFα response toward a T cell driven IFN⁃γ re⁃
nopharmacol，2017，49：126-131 sponse within the tumor microenvironment［J］. J Immuno⁃
［40］ GATUMU M K，SKARSTEIN K，PAPANDILE A，et al. ther Cancer，2021，9（6）：e002269
Blockade of lymphotoxin⁃beta receptor signaling reduces ［52］ KANG W，FENG Z C，LUO J W，et al. Tertiary lymphoid
aspects of Sjögren’s syndrome in salivary glands of non⁃ structures in cancer：the double⁃edged sword role in anti⁃
obese diabetic mice［J］. Arthritis Res Ther，2009，11（1）： tumor immunity and potential therapeutic induction strat⁃
R24 egies［J］. Front Immunol，2021，12：689270
［41］ DA SILVA ANTUNES R，MEHTA A K，MADGE L，et al. ［53］ GAO J J，SHI L Z，ZHAO H，et al. Loss of IFN⁃γ pathway
TNFSF14（LIGHT） exhibits inflammatory activities in genes in tumor cells as a mechanism of resistance to anti-
lung fibroblasts complementary to IL⁃13 and TGF⁃β［J］. CTLA⁃4 therapy［J］. Cell，2016，167（2）：397-404
Front Immunol，2018，9：576 ［54］ DE TREZ C. Lymphotoxin⁃beta receptor expression and
［42］ HERRO R，DA SILVA ANTUNES R，AGUILERA A R，et its related signaling pathways govern dendritic cell ho⁃
al. Tumor necrosis factor superfamily 14（LIGHT）controls meostasis and function［J］. Immunobiology，2012，217
thymic stromal lymphopoietin to drive pulmonary fibrosis （12）：1250-1258
［J］. J Allergy Clin Immunol，2015，136（3）：757-768 ［55］ ANNA J P，RUTH G. Therapeutic induction of tertiary
［43］ MIKAMI Y，MATSUZAKI H，HORIE M，et al. Lympho⁃ lymphoid structures in cancer through stromal remodeling
toxin β receptor signaling induces IL⁃8 production in hu⁃ ［J］. Front Immunol，2021，12：674375
man bronchial epithelial cells［J］. PLoS One，2014，9 ［收稿日期］ 2021-09-28
（12）：e114791 （责任编辑：蒋 莉）