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第43卷第10期 汪徐春,孙玉洁. 增强子调控异常与恶性肿瘤的关系研究进展[J].
2023年10月 南京医科大学学报(自然科学版),2023,43(10):1432-1440,1478 ·1439 ·
Biol,2020,17(11):1550-1559 hijacking activates GFI1 family oncogenes in medullo⁃
[20] LI W B,NOTANI D,MA Q,et al. Functional roles of en⁃ blastoma[J]. Nature,2014,511(7510):428-434
hancer RNAs for oestrogen⁃dependent transcriptional acti⁃ [34] MONTEFIORI L E,BENDIG S,GU Z H,et al. Enhancer
vation[J]. Nature,2013,498(7455):516-520 hijacking drives oncogenic BCL11B expression in lineage⁃
[21] BOSSÉ Y,AMOS C I. A decade of GWAS results in lung ambiguous stem cell leukemia[J]. Cancer Discov,2021,
cancer[J]. Cancer Epidemiol Biomarkers Prev,2018,27 11(11):2846-2867
(4):363-379 [35] GALA K,LI Q,SINHA A,et al. KMT2C mediates the es⁃
[22] HU Z B,WU C,SHI Y Y,et al. A genome⁃wide associa⁃ trogen dependence of breast cancer through regulation of
tion study identifies two new lung cancer susceptibility lo⁃ ERα enhancer function[J]. Oncogene,2018,37(34):
ci at 13q12.12 and 22q12.2 in Han Chinese[J]. Nat Gen⁃ 4692-4710
et,2011,43(8):792-796 [36] LV S,WEN H,SHAN X,et al. Loss of KMT2D induces
[23] XU J F,MO Z N,YE D W,et al. Genome⁃wide associa⁃ prostate cancer ROS⁃mediated DNA damage by suppress⁃
tion study in Chinese men identifies two new prostate can⁃ ing the enhancer activity and DNA binding of antioxidant
cer risk loci at 9q31.2 and 19q13.4[J]. Nat Genet,2012, transcription factor FOXO3[J]. Epigenetics,2019,14
44(11):1231-1235 (12):1194-1208
[24] WANG X C,CHENG H,YANG Y,et al. The enhancer [37] MAITITUOHETI M,KEUNG E Z,TANG M,et al. En⁃
rare germline variation rs548071605 contributes to lung hancer reprogramming confers dependence on glycolysis
cancer development[J]. Hum Mutat,2022,43(2):200- and IGF signaling in KMT2D mutant melanoma[J]. Cell
214 Rep,2020,33(3):108293
[25] GUAN W,YANG N,ZUO X,et al. Heritable variants in [38] GAO S,CHEN S,HAN D,et al. Chromatin binding of
the chromosome 1q22 locus increase gastric cancer risk FOXA1 is promoted by LSD1⁃mediated demethylation in
via altered chromatin looping and increased UBAP2L ex⁃ prostate cancer[J]. Nat Genet,2020,52(10):1011-1017
pression[J]. Mol Cancer Res,2021,19(12):1992-2002 [39] GOZDECKA M,MEDURI E,MAZAN M,et al. UTX⁃me⁃
[26] TIAN P,ZHONG M J,WEI G H. Mechanistic insights in⁃ diated enhancer and chromatin remodeling suppresses
to genetic susceptibility to prostate cancer[J]. Cancer myeloid leukemogenesis through noncatalytic inverse
Lett,2021,522:155-163 regulation of ETS and GATA programs[J]. Nat Genet,
[27] SHAO L P,ZUO X L,YANG Y,et al. The inherited varia⁃ 2018,50(6):883-894
tions of a p53 ⁃ responsive enhancer in 13q12.12 confer [40] D’OTO A,FANG J,JIN H,et al. KDM6B promotes acti⁃
lung cancer risk by attenuating TNFRSF19 expression[J]. vation of the oncogenic CDK4/6 ⁃ pRB ⁃ E2F pathway by
Genome Biol,2019,20(1):103 maintaining enhancer activity in MYCN⁃amplified neuro⁃
[28] HUA J T,AHMED M,GUO H Y,et al. Risk SNP⁃mediated blastoma[J]. Nat Commun,2021,12(1):7204
promoter⁃enhancerswitchingdrivesprostatecancer through [41] MAN N,MAS G,KARL D L,et al. p300 suppresses the
lncRNA PCAT19[J]. Cell,2018,174(3):564-575 transition of myelodysplastic syndromes to acute myeloid
[29] GAO P,XIA J H,SIPEKY C,et al. Biology and clinical leukemia[J]. JCI Insight,2021,6(19):e138478
implications of the 19q13 aggressive prostate cancer sus⁃ [42] MANSOUR M R,ABRAHAM B J,ANDERS L,et al. An
ceptibility locus[J]. Cell,2018,174(3):576-589 oncogenic super⁃enhancer formed through somatic muta⁃
[30] OLDRIDGE D A,WOOD A C,WEICHERT⁃LEAHEY N, tion of a noncoding intergenic element[J]. Science,2014,
et al. Genetic predisposition to neuroblastoma mediated 346(6215):1373-1377
by a LMO1 super ⁃ enhancer polymorphism[J]. Nature, [43] SAGHAFINIA S,MINA M,RIGGI N,et al. Pan⁃cancer
2015,528(7582):418-421 landscape of aberrant DNA methylation across human tu⁃
[31] HNISZ D,WEINTRAUB A S,DAY D S,et al. Activation mors[J]. Cell Rep,2018,25(4):1066-1080
of proto⁃oncogenes by disruption of chromosome neighbor⁃ [44] 唐思敏,邓雪婷,李全朋,等. 胆管癌的表观遗传学进展
hoods[J]. Science,2016,351(6280):1454-1458 [J]. 南京医科大学学报(自然科学版),2018,38(9):
[32] ZHANG X Y,CHOI P S,FRANCIS J M,et al. Somatic su⁃ 1322-1325
perenhancer duplications and hotspot mutations lead to [45] BELL R E,GOLAN T,SHEINBOIM D,et al. Enhancer
oncogenic activation of the KLF5 transcription factor[J]. methylation dynamics contribute to cancer plasticity and
Cancer Discov,2018,8(1):108-125 patient mortality[J]. Genome Res,2016,26(5):601-611
[33] NORTHCOTT P A,LEE C,ZICHNER T,et al. Enhancer [46] ARAN D,SABATO S,HELLMAN A. DNA methylation of