Page 52 - 南京医科大学学报自然科学版

南京医科大学学报（自然科学版） 第43卷第10期
·1378 · Journal of Nanjing Medical University（Natural Sciences） 2023年10月

·临床研究·

血清IL⁃9水平对急性脑梗死患者早期神经功能恶化的预测价值

吴旭明 ，徐宇浩 ，朱圆圆 2*
1
1
江苏大学附属医院神经内科，江苏 镇江 212001；江苏大学附属宜兴医院老年病科，江苏 宜兴 214221
1 2

［摘 要］ 目的：探讨血清白介素（interleukin，IL）⁃9 水平在急性脑梗死早期神经功能恶化（early neurological deterioration，
END）患者血清中的变化并评估其对END的预测价值。方法：收集106例脑梗死患者，根据是否发生END，将患者分为END组
42 例，非 END 组 64 例，收集患者的一般资料，并记录入院时美国国立卫生院神经功能缺损（National Institute of Health stroke
scale，NIHSS）评分，检测血清生化指标、基线期血清 IL⁃9、C 反应蛋白（C⁃reactive protein，CRP）和 IL⁃6 水平。相关性的评估采
用Pearson或Spearman相关性分析，采用Logistic 回归分析脑梗死患者发生END的影响因素，并绘制受试者工作特征（receiver
operating characteristic，ROC）曲线评估血清 IL⁃9 水平在脑梗死后发生 END 中的预测价值。结果：END 组糖尿病比例、颈动脉
狭窄>50%比例、低密度脂蛋白胆固醇、糖化血红蛋白、脑梗死体积和入院时NIHSS评分均高于非END组（P < 0.05）。END组
血清 IL⁃9 水平明显高于非 END 组（P < 0.01）。脑梗死患者血清 IL⁃9 水平与入院时 NIHSS 评分呈正相关（r=0.535，P < 0.01）。
Logistic 回归显示血清IL⁃9水平、颈动脉狭窄 > 50%、脑梗死体积和入院时NIHSS评分为END发生的危险因素（P < 0.01）。血
清 IL⁃9 水平预测 END 发生的 ROC 曲线下面积为 0.815。血清 IL⁃9 水平与血清 CRP 水平（r=0.648，P < 0.01）和 IL⁃6 水平
（r=0.765，P < 0.01）均呈正相关。结论：血清IL⁃9水平在脑梗死END患者中明显升高，对END的发生具有良好的预测作用。
［关键词］ 脑梗死；早期神经功能恶化；白介素⁃9；预测
［中图分类号］ R743.3 ［文献标志码］ A ［文章编号］ 1007⁃4368（2023）10⁃1378⁃07
doi：10.7655/NYDXBNS20231007

Predictive value of serum IL⁃9 level in the early deterioration of neurological function after
acute cerebral infarction

1 1 2*
WU Xuming ，XU Yuhao ，ZHU Yuanyuan
Department of Neurology，Affiliated Hospital of Jiangsu University，Zhenjiang 212001；Department of Geriatrics，the
1 2
Affiliated Yixing Hospital of Jiangsu University，Yixing 214221，China

［Abstract］ Objective：To explore the changes of serum interleukin（IL）⁃ 9 level in patients with acute cerebral infarction and
evaluate its value in prediction of early neurological deterioration（END）. Methods：A total of 106 patients with cerebral infarction
were collected. According to whether or not END occurred，the patients were divided into END group（42 cases）and non⁃END
group（64 cases）. The general data of patients were collected，and the National Institute of Health stroke scale（NIHSS）score was
recorded，and serum biochemical indexes，serum IL⁃9，C⁃reactive protein（CRP）and IL⁃6 levels at baseline were detected. Pearson or
Spearman correlation analysis was used to evaluate the correlation. Logistic regression was used to analyze the factors affecting the
occurrence of END in patients with cerebral infarction，and ROC curve was drawn to evaluate the predictive value of serum IL⁃9 level
in the occurrence of END after cerebral infarction. Results：The proportion of diabetes mellitus，carotid artery stenosis >50%，low
density lipoprotein，glycosylated hemoglobin，cerebral infarction volume and NIHSS score at admission in END group were all higher
than those in non⁃END group（P < 0.05）. The level of serum IL⁃9 in the END group was significantly higher than that in the non⁃END
group（P < 0.01）. The level of serum IL⁃9 in patients with cerebral infarction was positively correlated with NIHSS score at admission
（r=0.535，P < 0.01）. Logistic regression showed that serum IL⁃9 level，carotid artery stenosis >50%，cerebral infarction volume and
NIHSS score at admission were risk factors for END（P < 0.01）. The area under ROC curve of serum IL⁃ 9 level predicting END
occurrence was 0.815. Serum IL⁃9 level was positively correlated with serum CRP level（r=0.648，P < 0.01）and serum IL⁃6 level

［基金项目］ 国家自然科学基金（82101431）
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通信作者（Corresponding author），E⁃mail：707301875@qq.com