Page 139 - 南京医科大学学报自然科学版
P. 139

第43卷第2期            季学涛,张      许,刘   谨,等. 脂肪组织中自噬影响肥胖发病机制的研究进展[J].
                  2023年2月                     南京医科大学学报(自然科学版),2023,43(2):275-282                        ·281 ·


                    tive adipocyte differentiation in mice lacking the CEBPbe⁃  [26] PARRAY H A,YUN J W. Combined inhibition of autoph⁃
                    ta and or CEBPdelta gene[J]. EMBO J,1997,16(24):   agy protein 5 and galectin⁃1 by thiodigalactoside reduces

                    7432-7443                                          diet⁃induced obesity through induction of white fat brown⁃
               [13]LINHART H G,ISHIMURA⁃OKA K,DEMAYO F,et al.          ing[J]. IUBMB Life,2017,69(7):510-521
                    C/EBPalpha is required for differentiation of white,but  [27] HEINITZ S,GEBHARDT C,PIAGGI P,et al. Atg7 knock⁃
                    not brown,adipose tissue[J]. Proc Natl Acad Sci U S A,  down reduces chemerin secretion in murine adipocytes
                    2001,98(22):12532-12537                           [J]. J Clin Endocr Metab,2019,104(11):5715-5728
               [14] SAITO T,KUMA A,SUGIURA Y,et al. Autophagy regu⁃  [28] WANG X,WU R,LIU Y,et al. m(6)A mRNA methyla⁃
                    lates lipid metabolism through selective turnover of  tion controls autophagy and adipogenesis by targeting
                    NCoR1[J]. Nat Commun,2019,10(1):1567-1583          Atg5 and Atg7[J]. Autophagy,2020,16(7):1221-1235
               [15] GIAMPIERI F,AFRIN S,FORBES⁃HERNANDEZ T Y,    [29] RO S H,JUNG C H,HAHN W S,et al. Distinct functions
                    et al. Autophagy in human health and disease:novel ther⁃  of Ulk1 and Ulk2 in the regulation of lipid metabolism in
                    apeutic opportunities[J]. Antioxid Redox Signal,2019,  adipocytes[J]. Autophagy,2013,9(12):2103-2114
                    30(4):577-634                                [30] JIN Y,JI Y,SONG Y,et al. Depletion of adipocyte becn1
               [16] 王雨竹,张     许,李    仲. 成熟 SVFs 细胞与 Hepa1⁃6 细          leads to lipodystrophy and metabolic dysregulation[J]. Di⁃
                    胞共培养模型的建立及对肝细胞脂代谢的影响[J]. 南                         abetes,2021,70(1):182-195
                    京医科大学学报(自然科学版),2022,42(5):603-609            [31] WU H,WANG Y,LI W H,et al. Deficiency of mitophagy
               [17] WANG X Y,GUO M,WANG Q,et al. The patatin⁃like      receptor FUNDC1 impairs mitochondrial quality and ag⁃
                    phospholipase domain containing protein 7 facilitates  gravates dietary⁃induced obesity and metabolic syndrome
                    VLDL secretion by modulating ApoE stability[J]. Hepa⁃  [J]. Autophagy,2019,15(11):1882-1898
                    tology,2020,72(5):1569-1585                  [32] FERHAT M,FUNAI K,BOUDINA S. Autophagy in adi⁃
               [18] GHANDRIZ R,LERMAN L O. Renal cellular autophagy    pose tissue physiology and pathophysiology[J]. Antioxid
                    in obesity:boon or bane?[J]. Semin Nephrol,2021,41  Redox Signal,2019,31(6):487-501
                    (4):349-357                                  [33] YAU W W,SINGH B K,LESMANA R,et al. Thyroid hor⁃
               [19] CAO W Y,LI J H,YANG K P,et al. An overview of au⁃  mone(T3)stimulates brown adipose tissue activation via
                    tophagy:mechanism,regulation and research progress  mitochondrial biogenesis and MTOR⁃mediated mitophagy
                    [J]. B Cancer,2021,108(3):304-322                 [J]. Autophagy,2019,15(1):131-150
               [20] RAUTOU P E,MANSOURI A,LEBREC D,et al. Autoph⁃  [34] KO M S,YUN J Y,BAEK I J,et al. Mitophagy deficiency
                    agy in liver diseases[J]. J Hepatol,2010,53(6):1123-  increases NLRP3 to induce brown fat dysfunction in mice
                    1134                                              [J]. Autophagy,2021,17(5):1205-1221
               [21]GRUNWALD D S,OTTO N M,PARK J M,et al. GAB⁃    [35] ALTSHULER ⁃ KEYLIN S,KAJIMURA S. Mitochondrial
                    ARAPs and LC3s have opposite roles in regulating ULK1  homeostasis in adipose tissue remodeling[J]. Sci Signal,
                    for autophagy induction[J]. Autophagy,2020,16(4):  2017,10(468):9248-9273
                    600-614                                      [36] TAYLOR D,GOTTLIEB R A. Parkin⁃mediated mitopha⁃
               [22] BOOTH L,ROBERTS J L,AVOGADRI⁃CONNORS F,et          gy is downregulated in browning of white adipose tissue
                    al. The irreversible ERBB1/2/4 inhibitor neratinib inter⁃  [J]. Obesity,2017,25(4):704-712
                    acts with the BCL⁃2 inhibitor venetoclax to kill mammary  [37] LU X D,ALTSHULER⁃KEYLIN S,WANG Q,et al. Mi⁃
                    cancer cells[J]. Cancer Biol Ther,2018,19(3):239-247  tophagy controls beige adipocyte maintenance through a
               [23] KAROW M,FISCHER S,MESSLING S,et al. Functional     Parkin ⁃ dependent and UCP1 ⁃ independent mechanism
                    characterisation of the autophagy ATG12~5/16 complex  [J]. Sci Signal,2018,11(527):8526-8547
                    in dictyostelium discoideum[J]. Cells,2020,9(5):1179-  [38] LIU L,FENG D,CHEN G,et al. Mitochondrial outer ⁃
                    1202                                               membrane protein FUNDC1 mediates hypoxia ⁃ induced
               [24] DELORME⁃AXFORD E,KLIONSKY D J. The LC3⁃con⁃        mitophagy in mammalian cells[J]. Nat Cell Biol,2012,14
                    jugation machinery specifies cargo loading and secretion  (2):177-185
                    of extracellular vesicles[J]. Autophagy,2020,16(7):  [39] ROSA S C D,MARTENS M D,FIELD J T,et al. BNIP3L/
                    1169-1171                                          Nix ⁃ induced mitochondrial fission,mitophagy,and im⁃
               [25] AHMED M,NGUYEN H Q,HWANG J S,et al. Systemat⁃      paired myocyte glucose uptake are abrogated by PRKA/
                    ic characterization of autophagy⁃related genes during[J].  PKA phosphorylation[J]. Autophagy,2021,17(9):2257-
                    Oncotarget,2018,9(21):15526-15541                  2272
   134   135   136   137   138   139   140   141   142   143   144