Page 74 - 南京医科大学自然版

第45卷第10期
·1442 · 南 京 医 科 大 学 学 报 2025年10月

Conflict of Interests： cance and immune characteristics of APOE in gastric
All authors declare no conflict of interests. cancer［J］. Aging（Albany NY），2023，15（23）：13840-
作者贡献声明： 13853
王勇、丁磊、董汇昱负责实验实施、收集数据、统计分析、 ［11］HUANG J P，SUN W，WANG Z H，et al. FTO suppresses
论文撰写与修改。梁超、李杰负责课题设计、数据审核、论文 glycolysis and growth of papillary thyroid cancer via
修改与审阅。 decreasing stability of APOE mRNA in an N6 ⁃ methyl⁃
Author’s Contributions： adenosine⁃dependent manner［J］. J Exp Clin Cancer Res，

WANG Yong，DING Lei，and DONG Huiyu were responsi⁃ 2022，41（1）：42
ble for experimental implementation，data collection，statistical ［12］ ASHRAFIZADEH M，PASKEH M D A，MIRZAEI S，et
analysis，paper writing and revision. LIANG Chao and LI Jie al. Targeting autophagy in prostate cancer：preclinical
were responsible for the subject design，data review，manuscript and clinical evidence for therapeutic response［J］. J Exp
revision and review. Clin Cancer Res，2022，41（1）：105
［13］GILLESSEN S，BOSSI A，DAVIS I D，et al. Management
［参考文献］
of patients with advanced prostate cancer. partⅠ：inter⁃
［1］ SEKHOACHA M，RIET K，MOTLOUNG P，et al. Prostate
mediate ⁃/high ⁃ risk and locally advanced disease，bio⁃
cancer review：genetics，diagnosis，treatment options，and chemical relapse，and side effects of hormonal treatment：
alternative approaches［J］. Molecules，2022，27（17）：
report of the advanced prostate cancer consensus confe⁃
5730 rence 2022［J］. Eur Urol，2023，83（3）：267-293
［2］ CHEN H T，PANG B R，ZHOU C，et al. Prostate cancer⁃
［14］DELUCE J E，CARDENAS L，LALANI A K，et al. Emerg⁃
derived small extracellular vesicle proteins：the hope in ing biomarker ⁃ guided therapies in prostate cancer［J］.
diagnosis，prognosis，and therapeutics［J］. J Nanobiotech⁃
Curr Oncol，2022，29（7）：5054-5076
nology，2023，21（1）：480 ［15］KEMP S B，CARPENTER E S，STEELE N G，et al. Apoli⁃
［3］ LIU J Z，DONG L，ZHU Y J，et al. Prostate cancer treat⁃ poprotein E promotes immune suppression in pancreatic
ment⁃China’s perspective［J］. Cancer Lett，2022，550： cancer through NF ⁃ κB ⁃ mediated production of CXCL1
215927 ［J］. Cancer Res，2021，81（16）：4305-4318
［4］ PARKER C，CASTRO E，FIZAZI K，et al. Prostate cancer： ［16］WU C Y，LI T，CHENG W J. The correlation between
ESMO Clinical Practice Guidelines for diagnosis，treat⁃ APOE expression and the clinical characteristics and
ment and follow⁃up［J］. Ann Oncol，2020，31（9）：1119- prognosis of patients with endometrial cancer［J］. Medi⁃
1134 cine（Baltimore），2022，101（37）：e30536
［5］ KUMAR AM S，RAJAN P，ALKHAMEES M，et al. Pros⁃ ［17］FERRI⁃BORGOGNO S，ZHU Y，SHENG J T，et al. Spa⁃
tate cancer theragnostics biomarkers：an update［J］. tial transcriptomics depict ligand ⁃ receptor cross ⁃ talk
Investig Clin Urol，2024，65（6）：527-539 heterogeneity at the tumor⁃stroma interface in long⁃term
［6］ LEE S，DEVANNEY N A，GOLDEN L R，et al. APOE ovarian cancer survivors［J］. Cancer Res，2023，83（9）：
modulates microglial immunometabolism in response to 1503-1516
age，amyloid pathology，and inflammatory challenge［J］. ［18］LIU H K，GAO J W，FENG M，et al. Integrative molecular
Cell Rep，2023，42（3）：112196 and spatial analysis reveals evolutionary dynamics and
［7］ RAULIN A C，DOSS S V，TROTTIER Z A，et al. ApoE in tumor ⁃ immune interplay of in situ and invasive acral
Alzheimer’s disease：pathophysiology and therapeutic melanoma［J］. Cancer Cell，2024，42（6）：1067-1085.e11
strategies［J］. Mol Neurodegener，2022，17（1）：72 ［19］ZHU L，BAO Y L，LIU Z J，et al. Gualou⁃Xiebai herb pair
［8］ LIU Z，GAO Y，HAO F X，et al. Secretomes are a poten⁃ ameliorate atherosclerosis in HFD⁃induced ApoE -/- mice
tial source of molecular targets for cancer therapies and and inhibit the ox ⁃ LDL ⁃ induced injury of HUVECs by
indicate that APOE is a candidate biomarker for lung regulating the Nrf2⁃mediated ferroptosis［J］. J Ethnophar⁃
adenocarcinoma metastasis［J］. Mol Biol Rep，2014，41 macol，2024，326：117892
（11）：7507-7523 ［20］SAVIGNAC C，VILLENEUVE S，BADHWAR A，et al.
［9］ HE L Y，SHI M C，REN S W，et al. Jun⁃APOE⁃LRP1 axis APOE alleles are associated with sex ⁃ specific structural
promotes tumor metastasis in colorectal cancer［J］. Biomol differences in brain regions affected in Alzheimer’s disease
Biomed，2023，23（6）：1026-1037 and related dementia［J］. PLoS Biol，2022，20（12）：
［10］ PENG X L，CAI Z，CHEN D S，et al. Prognostic signifi⁃ （下转第1512页）