Page 79 - 南京医科大学自然版
P. 79
第45卷第10期 徐丽琴,许叶涛,张 敏. 妊娠期糖尿病合并血小板减少女性不良妊娠结局的影响因素
2025年10月 研究[J]. 南京医科大学学报(自然科学版),2025,45(10):1443-1454 ·1447 ·
表2 产后出血组与无产后出血组特征比较
Table 2 Characteristics comparison between women with and without postpartum hemorrhage
Characteristics Without postpartum hemorrhage(n=203) With postpartum hemorrhage(n=30) P
Age(years,x ± s) 31.84 ± 4.30 32.67 ± 5.05 0.339
Pregnancy times[n,M(P25,P75)] 2.00(1.00,3.00)0 2.00(2.00,3.50)0 0.050
Delivery history[n(%)] 85(41.9)0000 17(56.7)0000 0.184
Abortion history[n(%)] 100(49.3)00000 20(66.7)0000 0.113
Comorbidity[n(%)] 58(28.6)0000 13(43.3)0000 0.154
Assisted reproduction[n(%)] 19(9.4)00000 4(13.3)000 0.724
Late pregnancy BMI(kg/m ,x ± s) 26.72 ± 3.00 26.76 ± 3.03 0.967
2
Fetal position[n(%)] 0.254
Cephalic presentation 188(92.6)00000 30(100)000 0
Breech presentation 15(7.4)00000 0
PT[s,M(P25,P75)] 10.85(10.30,11.38) 11.30(10.70,11.62) 0.027
PT⁃INR[s,M(P25,P75)] 0.94(0.90,0.99)0 0.98(0.93,1.01)0 0.023
APTT[s,M(P25,P75)] 26.10(24.30,27.87) 26.50(24.20,29.25) 0.555
FIB[g/L,M(P25,P75)] 3.89(3.12,4.65)0 4.00(3.43,4.41)0 0.990
TT[s,M(P25,P75)] 16.40(15.70,17.30) 16.22(15.42,16.85) 0.642
D⁃dimer[mg/L,M(P25,P75)] 2.02(1.27,3.21)0 4.18(2.23,5.51)0 <0.001
HbA1c[%,M(P25,P75)] 5.11(4.90,5.40)0 5.00(4.74,5.25)0 0.240
OGTT[mmol/L,M(P25,P75)]
Fasting 4.86(4.47,5.24)0 4.64(4.36,5.09)0 0.122
1 h 10.20(9.22,10.91)0 9.82(9.13,10.54) 0.279
2 h 8.54(7.59,9.20)0 8.80(8.12,9.37)0 0.463
PLT[×10 /L,M(P25,P75)] 107.0(88.0,134.5)0 097.0(80.2,105.0)0 0.012
9
ALB[g/L,M(P25,P75)] 35.00(32.55,37.32) 39.65(35.43,42.90) 0.073
HSCRP[mg/L,M(P25,P75)] 2.06(0.99,5.00)0 5.00(1.60,9.38)0 0.167
PCT[%,M(P25,P75)] 0.13(0.11,0.15)0 0.11(0.10,0.14)0 0.130
HGB[g/L,M(P25,P75)] 122.0(114.0,132.0) 120.5(107.3,128.5) 0.305
Pregnant women outcomes
Delivery time(weeks,x ± s) 38.20 ± 2.12 38.83 ± 1.51 0.117
Cesarean[n(%)] 122(60.1)00000 10(33.3)0 0.010
Preterm delivery[n(%)] 25(12.3)0000 1(3.3)0 00 0.251
Premature rupture of membranes[n(%)] 33(16.3)0000 5(16.7)00 1.000
Intrapartum hemorrhage[mL,M(P25,P75)] 300.0(250.0,400.0) 500.0(412.5,800.0) <0.001
Postpartum hemorrhage[mL,M(P25,P75)] 450.0(352.5,563.8) 0 722.5(544.5,1 092.5) <0.001
Newborn outcomes
Weight(g,x ± s) 3 352.36 ± 639.81 3 514.87 ± 486.57 0.183
Female[n(%)] 92(45.3)0000 16(53.3)0000 0.532
5 min Apgar score[n(%)] 1.000
7 2(1.0)0000 0
8-10 201(99.0)00000 30(100)0000
Neonatal distress[n(%)] 12(5.9)00000 0 0.355
NICU[n(%)] 39(19.2)0000 4(13.3)000 0.601
3.8‰。然而,GDM 合并 TCP 产妇产后出血、早产、 D⁃二聚体、血小板及孕晚期BMI是主要不良母婴结
新生儿体重异常等母婴不良妊娠结局发生率较 局的影响因素。
高。多因素回归分析表明,空腹血糖、其他合并症、 本研究发现,产后出血是GDM合并TCP产妇主

