Page 137 - 南京医科大学自然版

第45卷第3期 李建璋，张洁贞，周 琳. U2 snRNP：肿瘤发生发展中的关键介质［J］.
2025年3月 南京医科大学学报（自然科学版），2025，45（3）：418-425 ·425 ·

［14］STANLEY R F，ABDEL⁃WAHAB O. Dysregulation and hotspot mutation in prolactinomas［J］. Nat Commun，
therapeutic targeting of RNA splicing in cancer［J］. Nat 2020，11（1）：2506
Cancer，2022，3（5）：536-546 ［27］GUO J，LI C Z，FANG Q Y，et al. The SF3B1 R625H muta⁃
［15］HU Z，WU C，SHI Y，et al. A genome⁃wide association tion promotes prolactinoma tumor progression through ab⁃
study identifies two new lung cancer susceptibility loci at errant splicing of DLG1［J］. J Exp Clin Cancer Res，2022，
13q12.12 and 22q12.2 in Han Chinese［J］. Nature genet⁃ 41（1）：26
ics，2011，43：792-796 ［28］WANG H H，LIU F L，BAI C X，et al. PHF5A promotes
［16］BROOKS A N，CHOI P S，DEWAAL L，et al. A pan⁃can⁃ proliferation and migration of non⁃small cell lung cancer⁃
cer analysis of transcriptomechanges associated with so⁃ by regulating of PI3K/AKT pathway［J］. Chin J Lung Can⁃
matic mutations in U2AF1 reveals commonly altered cer，2023，26（1）：10-16
splicing events［J］. PLoS One，2014，9：e87361 ［29］ZHAN X，YAN C，ZHANG X，et al. Structures of the hu⁃
［17］OKEYO⁃OWUOR T，WHITE B S，CHATRIKHI R，et al. man pre⁃catalytic spliceosome and its precursor spliceo⁃
U2AF1 mutations alter sequence specificity of pre⁃mRNA some［J］. Cell Res，2018，28：1129-1140
binding and splicing［J］. Leukemia，2015，29：909-917 ［30］LIU K L，YIN Y W，LU B S，et al. E2F6/KDM5C pro⁃
［18］TENG T，TSAI J H，PUYANG X L，et al. Splicing modula⁃ motes SF3A3 expression and bladder cancer progression
tors act at the branch point adenosine binding pocket de⁃ through a specific hypomethylated DNA promoter［J］.
fined by the PHF5A ⁃ SF3b complex［J］. Nat Commun， Cancer Cell Int，2022，22（1）：109
2017，8：15522 ［31］GUELFI S，HODIVALA⁃DILKE K，BERGERS G. Target⁃
［19］LI J，YU B，DENG P，et al. KDM3 epigenetically controls ing the tumour vasculature：from vessel destruction to pro⁃
tumorigenic potentials of human colorectal cancer stem motion［J］. Nat Rev Cancer，2024，24（10）：655-675
cells through Wnt/β⁃catenin signalling［J］. Nat Commun， ［32］FURUMAI R，UCHIDA K，KOMI Y，et al. Spliceostatin A
2017，8：15146 blocks angiogenesis by inhibiting global gene expression
［20］CHANG Y，ZHAO Y L，WANG L Y，et al. PHF5A pro⁃ including VEGF［J］. Cancer Sci，2010，101（11）：2483-
motes colorectal cancerprogression by alternative splicing 2489
of TEAD2［J］. Mol Ther Nucleic Acids，2021，26：1215- ［33］LOO Y M，GALE M. Immune signaling by RIG⁃I⁃like re⁃
1227 ceptors［J］. Immunity，2011，34（5）：680-692
［21］YU H，LIN L B，ZHANG Z Q，et al. Targeting NF ⁃ κB ［34］CHANG A Y，ZHOU Y J，IYENGAR S，et al. Modulation
pathway for the therapy of diseases：mechanism and clini⁃ of SF3B1 in the pre⁃mRNA spliceosome induces a RIG⁃Ⅰ
cal study［J］. Signal Transduct Target Ther，2020，5（1）： ⁃dependent type Ⅰ IFN response［J］. J Biol Chem，2021，
209 297（5）：101277
［22］AJIBADE A A，WANG Q F，CUI J，et al. TAK1 negative⁃ ［35］YOU H M，WANG L，MENG H W，et al. Pyroptosis：shed⁃
ly regulates NF⁃κB and p38 MAP kinase activation in Gr⁃1+ ding light on the mechanisms and links with cancers［J］.
CD11b+neutrophils［J］. Immunity，2012，36（1）：43-54 Front Immunol，2023，14：1290885
［23］LIU B，LIU Z Q，CHEN S S，et al. Mutant SF3B1 pro⁃ ［36］WARREN C F A，WONG⁃BROWN M W，BOWDEN N A.
motes AKT⁃and NF⁃κB⁃driven mammary tumorigenesis［J］. BCL⁃2 family isoforms in apoptosis and cancer［J］. Cell
J Clin Invest，2021，131（1）：e138315 Death Dis，2019，10（3）：177
［24］YANG Q，ZHANG J，XU S，et al. Knockdown of PHF5A ［37］POPLI P，RICHTERS M M，CHADCHAN S B，et al. Splic⁃
inhibits migration and invasion of HCC cells via eownreg⁃ ing factor SF3B1 promotes endo⁃metrial cancer progres⁃
ulating NF⁃κB signaling［J］. Biomed Res Int，2019，2019： sion via regulating KSR2 RNA maturation［J］. Cell Death
1621854 Dis，2020 ，11（10）：842
［25］WANG J，HUANG T J，MEI Y，et al. Novel long noncod⁃ ［38］WANG S R，LIU Y，XIAO H M，et al. Inhibition of SF3B1
ing RNA LINC02820 augments TNF signaling pathway to improves the immune microenvironment through pyropto⁃
remodel cytoskeleton and potentiate metastasis in esopha⁃ sis and synergizes with αPDL1 in ovarian cancer［J］. Cell
geal squamous cell carcinoma［J］. Cancer Gene Ther， Death Dis，2023，14（11）：775

2023，30（2）：375-387 ［收稿日期］ 2024-10-10
［26］LI C Z，XIE W Y，ROSENBLUM J S，et al. Somatic SF3B1 （本文编辑：陈汐敏）