Page 138 - 南京医科大学自然版

南京医科大学学报（自然科学版） 第45卷第3期
·426 · Journal of Nanjing Medical University（Natural Sciences） 2025年3月

·综 述·

成纤维细胞在胃黏膜癌变及胃癌药物治疗中的研究进展

韩经略，安方梅 *
南京医科大学附属无锡人民医院消化内科，南京医科大学无锡医学中心，国家消化系统疾病临床医学研究中心（西安）江苏省

分中心，江苏 无锡 214023

［摘 要］ 成纤维细胞在细胞外基质的合成与重塑中发挥重要作用，参与维持组织结构、介导免疫调节、炎症及肿瘤发生等生
理病理过程。在胃黏膜癌变前期，成纤维细胞就参与并维持了胃黏膜的萎缩与化生。当胃黏膜癌变后，被激活的成纤维细胞
通过与胃癌细胞及肿瘤微环境中的其他组分相互作用，塑造了适合胃癌生长的微环境从而促进胃癌的增殖、侵袭和转移，但作
用机制复杂，仍需要进一步探索。同时，成纤维细胞被发现与胃癌的化疗耐药密切相关。因此，以成纤维细胞为靶点的药物可
能为癌症治疗提供新的方向，并在降低癌症复发转移风险，减少化疗耐药，改善癌症预后方面发挥重要作用。文章就成纤维细
胞促进胃黏膜癌变的作用机制及其在胃癌药物治疗效果评价中作一综述，为成纤维细胞在胃癌发病及治疗中的作用研究提供
理论基础。
［关键词］ 成纤维细胞；胃癌；预后；治疗
［中图分类号］ R735.2 ［文献标志码］ A ［文章编号］ 1007⁃4368（2025）03⁃426⁃09
doi：10.7655/NYDXBNSN240867

Research progress of fibroblasts in gastric mucosal carcinogenesis and drug therapy of
gastric cancer
*
HAN Jinglüe，AN Fangmei
Department of Gastroenterology，the Affiliated Wuxi People’s Hospital of Nanjing Medical University，Wuxi Medical
Center，Nanjing Medical University，Jiangsu Branch of the National Clinical Research Center for Digestive Diseases
（Xi’an），Wuxi 214023，China

［Abstract］ Fibroblasts play important functions in the synthesis and remodeling of extracellular matrix and are involved in
physiopathological processes such as maintaining tissue structure，mediating immune regulation，inflammation and tumorigenesis.
Fibroblasts participate in and maintain the atrophy and chemotaxis of the gastric mucosa in the precancerous stage. When the gastric
mucosa becomes cancerous，the activated fibroblasts interact with gastric cancer cells and other components of the tumor
microenvironment，shaping a microenvironment suitable for the growth of gastric cancer and thus promoting gastric cancer proliferation，
invasion，and metastasis，but the mechanism of action is complex and needs to be further explored. Meanwhile，fibroblasts have been
found to be closely associated with chemoresistance in gastric cancer. Therefore，drugs targeting fibroblasts may provide a new
direction for cancer treatment and play an important role in reducing the risk of cancer recurrence and metastasis，decreasing
chemoresistance and improving cancer prognosis. In this study，we provide a review on the mechanism of fibroblasts promoting gastric
mucosal carcinogenesis and their role in evaluating the effect of gastric cancer drug therapy，in order to provide a theoretical basis for
the study of the role of fibroblasts in the pathogenesis and treatment of gastric cancer.
［Key words］ fibroblast；gastric cancer；prognosis；therapy
［J Nanjing Med Univ，2025，45（03）：426⁃434］

［基金项目］ 江苏省自然科学基金（BK20211039）；无锡市双百拔尖人才项目（BJ2023008）；南京医科大学无锡医学中心专病
队列和临床研究项目（WMCC202302）；南京医科大学无锡医学中心重点项目（WMCM202305）
通信作者（Corresponding author），E⁃mail：fangmeian@njmu.edu.cn（ORCID：0000⁃0001⁃5392⁃2891）
∗