Page 114 - 南京医科大学自然版

南京医科大学学报（自然科学版） 第45卷第8期
·1170 · Journal of Nanjing Medical University（Natural Sciences） 2025年8月

·临床研究·

CT引导下经皮液氮冷冻消融治疗老年肺恶性肿瘤的有效性及

安全性

黄义勤 ，周 勇 ，刘艳虎 ，李亚东 ，甄福喜 ，李庆国 1，2*
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南京医科大学第二附属医院胸外科，心血管中心，江苏 南京 210011；南京医科大学第一附属医院胸外科，江苏 南京 210029
［摘 要］ 目的：探讨CT引导下经皮液氮冷冻消融治疗老年肺恶性肿瘤的临床价值。方法：回顾性分析2023年1—12月接受
CT引导下经皮液氮冷冻消融治疗的56例老年肺恶性肿瘤患者（根治组49例，姑息组7例）的临床资料。采用改良实体瘤疗效
评价标准（modified response evaluation criteria in solid tumors，mRECIST）评估术后疗效，记录并发症、视觉模拟评分（visual ana⁃
logue scale，VAS）、C⁃反应蛋白（C⁃reactive protein，CRP）及美国东部肿瘤协作组（Eastern Cooperative Oncology Group Score，
ECOG）评分变化。结果：56例均成功完成手术，气胸发生率28.57%（16/56），经治疗后恢复良好。根治组术后1、3、6个月完全
缓解率分别为100.00%、91.83%、83.67%，姑息组部分缓解率分别为100.00%、85.71%、57.14%。ECOG评分从术前（3.2±0.6）分
降至术后6个月（1.3±0.4）分（P < 0.01）。结论：该技术安全有效，尤其适用于无法手术的老年患者，根治性消融短期疗效显著，
姑息性治疗可改善生活质量。
［关键词］ 肺肿瘤；液氮冷冻消融；体层摄影术；CT引导

［中图分类号］ R734.2 ［文献标志码］ A ［文章编号］ 1007⁃4368（2025）08⁃1170⁃08
doi：10.7655/NYDXBNSN250131

Efficacy and safety of CT ⁃ guided percutaneous liquid nitrogen cryoablation for the
treatment of lung malignancies in the elderly
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HUANG Yiqin ，ZHOU Yong ，LIU Yanhu ，LI Yadong ，ZHEN Fuxi ，LI Qingguo 1，2*
Department of Thoracic Surgery，Cardiovascular Center，the Second Affiliated Hospital of Nanjing Medical
1 2
University，Nanjing 210011；Department of Thoracic Surgery，the First Affiliated Hospital of Nanjing Medical
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University，Nanjing 210029，China
［Abstract］ Objective：To evaluate the clinical value of CT ⁃ guided percutaneous nitrogen cryoablation for elderly patients with
pulmonary malignancies. Methods：Clinical data of 56 elderly patients（49 in the radical group，7 in the palliative group）who
underwent CT⁃guided percutaneous cryoablation from January to December 2023 were retrospectively analyzed. Treatment efficacy was
assessed by modified response evaluation criteria in solid tumors（mRECIST），with complications，visual analogue scale（VAS），C⁃
reactive protein（CRP）and Eastern Cooperative Oncology Group Score（ECOG）scores recorded. Results：All 56 procedures were
successfully completed，with a pneumothorax incidence of 28.57%（16/56），all recovering well after treatment. The complete response
rates in the radical group at 1，3，and 6 months postoperatively were 100.00%，91.83%，and 83.67%，respectively，whereas the partial
response rates in the palliative group were 100.00%，85.71%，and 57.14%. The ECOG score decreased from a preoperative value of
3.2±0.6 to 1.3±0.4 at 6 months postoperatively（P < 0.01）. Conclusion：This technique is safe and effective，particularly suitable for
elderly patients ineligible for surgery. Radical ablation demonstrates significant short⁃term efficacy，while palliative treatment improves
quality of life.
［Key words］ lung tumor；composite liquid nitrogen solid tumor ablation；tomography；CT guidance
［J Nanjing Med Univ，2025，45（08）：1170⁃1177］

［基金项目］ 江苏省重点研发计划（社会发展）（BE2021749）
通信作者（Corresponding author），E⁃mail：liqg@njmu.edu.cn（ORCID：0000⁃0002⁃0625⁃7531）
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