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               ·186 ·                            南 京    医 科 大 学 学         报                        2026年2月


              要通过未来进一步的大样本、多中心研究验证。②本                                nosis of mechanical thrombectomy for acute stroke by ma⁃
              研究中梗死核心体积的测量仅运用病变侧大脑半                                  chine learning combined with radiomics features[J]. Jour⁃
              球 CBF 小于健侧大脑半球相同区域 30%的体积这                             nal of Nanjing Medical University(Natural Sciences),
              单一阈值,并未使用其他CBF阈值或使用脑血流量                                2022,42(8):1165-1170
                                                                [4] NOGUEIRA R G,JADHAV A P,HAUSSEN D C,et al.
              的阈值标准进行梗死核心体积测量的比较。
                                                                     Thrombectomy 6 to 24 hours after stroke with a mismatch
                  综上所述,本研究发现部分 NCCT⁃CTP 不匹配
                                                                     between deficit and infarct[J]. N Engl J Med,2018,378:
              患者可从EVT中获益。影像评估前接受IVT以及更
                                                                     11-21
              高的基线NIHSS评分是出现NCCT⁃CTP不匹配的独                       [5] ALBERS G W,MARKS M P,KEMP S,et al. Thrombecto⁃
              立影响因素。本研究认为应该考虑发生NCCT⁃CTP                              my for stroke at 6 to 16 hours with selection by perfusion
              不匹配的影响因素,在临床决策过程中,充分结合                                 imaging[J]. N Engl J Med,2018,378:708-718
              临床因素,为此类患者实施合理的临床决策。                              [6] KONG W Y,TAN B Y Q,NGIAM N J H et al. Validation
                  利益冲突声明:                                            of serial alberta stroke program early CT score as an out⁃
                  所有作者声明不存在利益冲突。                                     come predictor in thrombolyzed stroke patients[J]. J
                  Conflict of Interests:                             Stroke Cerebrovasc Dis,2017,36:2264-2271
                                                                [7] SUI Y,CHEN W,CHEN C,et al. CTP⁃defined large core
                  The authors declare no conflict of interests.
                  作者贡献声明:                                            is a better predictor of poor outcome for endovascular
                  张强负责数据收集、数据整理、撰写初稿、校对和编辑;                          treatment than ASPECTS⁃defined large core[J]. Stroke,
              褚玥负责数据收集、数据整理、审阅和编辑论文;马高负责数                            2024,55:1227-1234
              据收集、数据整理、审阅和编辑论文;沈咣辰负责数据收集、                       [8] 李晓慧,陈旭锋,汪        璇,等. 核心梗死体积对大血管闭
              数据分析、数据可视化;施海彬审阅和编辑论文;吴飞云负责                            塞性急性缺血性脑卒中早期临床预后的预测价值[J].
              方法设计、审阅和编辑论文。                                          南京医科大学学报(自然科学版),2022,42(12):1716-
                  Author’s Contributions:                            1721
                                                                     LI X H,CHEN X F,WANG X,et al. The predictive value
                  ZHANG Qiang was responsible for data collection,organi⁃
                                                                     of core infarction volume for the early clinical prognosis
              zation,and manuscript writing;CHU Yue and MA Gao were re⁃
                                                                     of large vessel occlusive acute ischemic stroke[J]. Jour⁃
              sponsible for data collection,reviewing and editing the manu⁃
              script;SHEN Guangchen was responsible for data collection,  nal of Nanjing Medical University(Natural Sciences),
                                                                     2022,42(12):1716-1721
              analysis,and visualization;SHI Haibin participated in manu⁃
                                                                [9] HUO X,MA G,TONG X et al. Trial of endovascular ther⁃
              script writing;WU Feiyun was responsible for experimental de⁃
                                                                     apy for acute ischemic stroke with large infarct[J]. N
              sign,fund support,and manuscript revision.
                                                                     Engl J Med,2023,388:1272-1283
             [参考文献]
                                                                [10]HAUSSEN D C,DEHKHARGHANI S,RANGARAJU S,
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                   学分会卒中学组,中国卒中学会急救医学分会. 急性缺                         non⁃contrast CT ASPECTS(Alberta stroke program early
                   血性脑卒中急诊急救中国专家共识2018[J]. 中国卒中                      CT score):correlation and clinical outcome prediction in
                   杂志,2018,13(9):956-967                             large vessel stroke[J]. Stroke,2016,47:2318-2322
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                   ciety,Stroke Group of the Emergency Medicine Branch of  tween alberta stroke program early CT score and perfu⁃
                   the Chinese Medical Association,Emergency Medicine  sion imaging may be a good variable for endovascular
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                  [J]. Chinese Journal of Stroke,2018,13(9):956-967  tions on angiographic revascularization grading standards
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             [3] 陈罕奇,张       浩,葛晓敏,等. 机器学习结合影像组学特                    with alteplase 3 to 4.5 hours after acute ischemic stroke[J].
                   征预测急性脑卒中机械取栓预后[J].南京医科大学学                         J Engl J Med,2008,359:1317-1329
                   报(自然科学版),2022,42(8):1165-1170                [14]LIN K,RAPALINO O,LAW M,et al. Accuracy of the al⁃
                   CHEN H Q,ZHANG H,GE X M,et al. Prediction of prog⁃  berta stroke program early CT score during the first 3
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