Page 55 - 《南京医科大学学报(自然科学版)》2026年第3期
P. 55

第46卷第3期               焦   艺,赵廷昱,刘凌翔. 胸腺上皮肿瘤免疫治疗进展与不良事件管理[J].
                  2026年3月                    南京医科大学学报(自然科学版),2026,46(3):355-365,374                     ·363 ·


                   Author’s Contributions:                             a multicentre,single⁃arm,phase 2 trial[J]. Lancet Oncol,
                   JIAO Yi was responsible for the writing and editing of original  2025,26(3):331-342
                draft. ZHAO Tingyu was responsible for the writing of original  [12]GIACCONE G,KIM C. Durable response in patients with
                draft. LIU Lingxiang was responsible for conceptualization and  thymic carcinoma treated with pembrolizumab after
                supervision.                                           prolonged follow⁃up[J]. J Thorac Oncol,2021,16(3):
               [参考文献]                                                  483-485
                                                                 [13]MANIAR R,LOEHRER P J Sr. Understanding the land⁃
               [1] RIOJA P,RUIZ R,GALVEZ⁃NINO M,et al.Epidemiology
                                                                       scape of immunotherapy in thymic epithelial tumors[J].
                    of thymic epithelial tumors:22 ⁃ years experience from a
                                                                       Cancer,2023,129(8):1162-1172
                    single⁃institution[J]. Thorac Cancer,2021,12(4):420-
                                                                 [14]WANG W X,LIN G,HAO Y,et al. Treatment outcomes
                    425
                                                                       and prognosis of immune checkpoint inhibitors therapy in
               [2] MARX A,CHAN J K C,CHALABREYSSE L,et al. The
                                                                       patients with advanced thymic carcinoma:a multicentre
                    2021 WHO classification of tumors of the thymus and
                                                                       retrospective study[J]. Eur J Cancer,2022,174:21-30
                    mediastinum:what is new in thymic epithelial,germ cell,
                                                                 [15]ALAM S M,TRAVERS P J,WUNG J L,et al. T⁃cell⁃
                    and mesenchymal tumors?[J]. J Thorac Oncol,2022,17
                                                                       receptor affinity and thymocyte positive selection[J].
                    (2):200-213
                                                                       Nature,1996,381(6583):616-620
               [3] TARTARONE A,LEROSE R,LETTINI A R,et al. Current
                                                                 [16] STARR T K,JAMESON S C,HOGQUIST K A. Positive
                    treatment approaches for thymic epithelial tumors[J]. Life  and negative selection of T cells[J]. Annu Rev Immunol,
                    (Basel),2023,13(5):1170
                                                                       2003,21:139-176
               [4] BERGHMANS T,DURIEUX V,HOLBRECHTS S,et al.
                                                                 [17] IRLA M. Instructive cues of thymic T cell selection[J].
                    Systemic treatments for thymoma and thymic carcinoma:
                                                                       Annu Rev Immunol,2022,40:95-119
                    a systematic review[J]. Lung Cancer,2018,126:25-31  [18]MCDONALD B D,BUNKER J J,ERICKSON S A,et al.
               [5] ZUCALI P A,DE PAS T,PALMIERI G,et al. PhaseⅡ
                                                                       Crossreactive αβ T cell receptors are the predominant
                    study of everolimus in patients with thymoma and thymic  targets of thymocyte negative selection[J]. Immunity,
                    carcinoma previously treated with cisplatin⁃based chemo⁃
                                                                       2015,43(5):859-869
                    therapy[J]. J Clin Oncol,2018,36(4):342-349  [19]SURH C D,SPRENT J. T⁃cell apoptosis detected in situ
               [6] THOMAS A,RAJAN A,BERMAN A,et al. Sunitinib in
                                                                       during positive and negative selection in the thymus[J].
                    patients with chemotherapy ⁃ refractory thymoma and  Nature,1994,372(6501):100-103
                    thymic carcinoma:an open⁃label phase 2 trial[J]. Lancet  [20]ASHBY K M,HOGQUIST K A. Author correction:a guide
                    Oncol,2015,16(2):177-186                           to thymic selection of T cells[J]. Nat Rev Immunol,
               [7] GIACCONE G,KIM C,THOMPSON J,et al. Pembroli⁃        2023,23(10):697
                     zumab in patients with thymic carcinoma:a single⁃arm,  [21]SHINZAWA M,MOSEMAN E A,GOSSA S,et al. Reversal
                     single⁃centre,phase 2 study[J]. Lancet Oncol,2018,19  of the T cell immune system reveals the molecular basis
                    (3):347-355                                        for T cell lineage fate determination in the thymus[J].
               [8] CHO J,KIM H S,KU B M,et al. Pembrolizumab for       Nat Immunol,2022,23(5):731-742
                    patients with refractory or relapsed thymic epithelial  [22]NITTA T,MURATA S,UENO T,et al. Thymic microenvi⁃
                    tumor:an open ⁃ label phase Ⅱ trial[J]. J Clin Oncol,  ronments for T⁃cell repertoire formation[J]. Adv Immunol,
                    2019,37(24):2162-2170                              2008,99:59-94
               [9] KATSUYA Y,HORINOUCHI H,SETO T,et al. Single⁃arm,  [23] HU Z C,LANCASTER J N,SASIPONGANAN C,et al.
                    multicentre,phaseⅡtrial of nivolumab for unresectable or  CCR4 promotes medullary entry and thymocyte⁃dendritic
                    recurrent thymic carcinoma:PRIMER study[J]. Eur J  cell interactions required for central tolerance[J]. J Exp
                    Cancer,2019,113:78-86                              Med,2015,212(11):1947-1965
               [10]ZHAO C,RAJAN A. Immune checkpoint inhibitors for  [24]PUNT J A,OSBORNE B A,TAKAHAMA Y,et al. Nega⁃
                                                                                      +
                    treatment of thymic epithelial tumors:how to maximize  tive selection of CD4 CD8 thymocytes by T cell receptor⁃
                                                                                         +
                    benefit and optimize risk?[J]. Mediastinum,2019,3:35  induced apoptosis requires a costimulatory signal that can
               [11] SHUKUYA T,ASAO T,GOTO Y,et al. Activity and safety  be provided by CD28[J]. J Exp Med,1994,179(2):709-
                    of atezolizumab plus carboplatin and paclitaxel in patients  713
                    with advanced or recurrent thymic carcinoma(MARBLE):  [25]BREED E R,WATANABE M,HOGQUIST K A. Measuring
   50   51   52   53   54   55   56   57   58   59   60