Page 55 - 《南京医科大学学报(自然科学版)》2026年第3期
P. 55
第46卷第3期 焦 艺,赵廷昱,刘凌翔. 胸腺上皮肿瘤免疫治疗进展与不良事件管理[J].
2026年3月 南京医科大学学报(自然科学版),2026,46(3):355-365,374 ·363 ·
Author’s Contributions: a multicentre,single⁃arm,phase 2 trial[J]. Lancet Oncol,
JIAO Yi was responsible for the writing and editing of original 2025,26(3):331-342
draft. ZHAO Tingyu was responsible for the writing of original [12]GIACCONE G,KIM C. Durable response in patients with
draft. LIU Lingxiang was responsible for conceptualization and thymic carcinoma treated with pembrolizumab after
supervision. prolonged follow⁃up[J]. J Thorac Oncol,2021,16(3):
[参考文献] 483-485
[13]MANIAR R,LOEHRER P J Sr. Understanding the land⁃
[1] RIOJA P,RUIZ R,GALVEZ⁃NINO M,et al.Epidemiology
scape of immunotherapy in thymic epithelial tumors[J].
of thymic epithelial tumors:22 ⁃ years experience from a
Cancer,2023,129(8):1162-1172
single⁃institution[J]. Thorac Cancer,2021,12(4):420-
[14]WANG W X,LIN G,HAO Y,et al. Treatment outcomes
425
and prognosis of immune checkpoint inhibitors therapy in
[2] MARX A,CHAN J K C,CHALABREYSSE L,et al. The
patients with advanced thymic carcinoma:a multicentre
2021 WHO classification of tumors of the thymus and
retrospective study[J]. Eur J Cancer,2022,174:21-30
mediastinum:what is new in thymic epithelial,germ cell,
[15]ALAM S M,TRAVERS P J,WUNG J L,et al. T⁃cell⁃
and mesenchymal tumors?[J]. J Thorac Oncol,2022,17
receptor affinity and thymocyte positive selection[J].
(2):200-213
Nature,1996,381(6583):616-620
[3] TARTARONE A,LEROSE R,LETTINI A R,et al. Current
[16] STARR T K,JAMESON S C,HOGQUIST K A. Positive
treatment approaches for thymic epithelial tumors[J]. Life and negative selection of T cells[J]. Annu Rev Immunol,
(Basel),2023,13(5):1170
2003,21:139-176
[4] BERGHMANS T,DURIEUX V,HOLBRECHTS S,et al.
[17] IRLA M. Instructive cues of thymic T cell selection[J].
Systemic treatments for thymoma and thymic carcinoma:
Annu Rev Immunol,2022,40:95-119
a systematic review[J]. Lung Cancer,2018,126:25-31 [18]MCDONALD B D,BUNKER J J,ERICKSON S A,et al.
[5] ZUCALI P A,DE PAS T,PALMIERI G,et al. PhaseⅡ
Crossreactive αβ T cell receptors are the predominant
study of everolimus in patients with thymoma and thymic targets of thymocyte negative selection[J]. Immunity,
carcinoma previously treated with cisplatin⁃based chemo⁃
2015,43(5):859-869
therapy[J]. J Clin Oncol,2018,36(4):342-349 [19]SURH C D,SPRENT J. T⁃cell apoptosis detected in situ
[6] THOMAS A,RAJAN A,BERMAN A,et al. Sunitinib in
during positive and negative selection in the thymus[J].
patients with chemotherapy ⁃ refractory thymoma and Nature,1994,372(6501):100-103
thymic carcinoma:an open⁃label phase 2 trial[J]. Lancet [20]ASHBY K M,HOGQUIST K A. Author correction:a guide
Oncol,2015,16(2):177-186 to thymic selection of T cells[J]. Nat Rev Immunol,
[7] GIACCONE G,KIM C,THOMPSON J,et al. Pembroli⁃ 2023,23(10):697
zumab in patients with thymic carcinoma:a single⁃arm, [21]SHINZAWA M,MOSEMAN E A,GOSSA S,et al. Reversal
single⁃centre,phase 2 study[J]. Lancet Oncol,2018,19 of the T cell immune system reveals the molecular basis
(3):347-355 for T cell lineage fate determination in the thymus[J].
[8] CHO J,KIM H S,KU B M,et al. Pembrolizumab for Nat Immunol,2022,23(5):731-742
patients with refractory or relapsed thymic epithelial [22]NITTA T,MURATA S,UENO T,et al. Thymic microenvi⁃
tumor:an open ⁃ label phase Ⅱ trial[J]. J Clin Oncol, ronments for T⁃cell repertoire formation[J]. Adv Immunol,
2019,37(24):2162-2170 2008,99:59-94
[9] KATSUYA Y,HORINOUCHI H,SETO T,et al. Single⁃arm, [23] HU Z C,LANCASTER J N,SASIPONGANAN C,et al.
multicentre,phaseⅡtrial of nivolumab for unresectable or CCR4 promotes medullary entry and thymocyte⁃dendritic
recurrent thymic carcinoma:PRIMER study[J]. Eur J cell interactions required for central tolerance[J]. J Exp
Cancer,2019,113:78-86 Med,2015,212(11):1947-1965
[10]ZHAO C,RAJAN A. Immune checkpoint inhibitors for [24]PUNT J A,OSBORNE B A,TAKAHAMA Y,et al. Nega⁃
+
treatment of thymic epithelial tumors:how to maximize tive selection of CD4 CD8 thymocytes by T cell receptor⁃
+
benefit and optimize risk?[J]. Mediastinum,2019,3:35 induced apoptosis requires a costimulatory signal that can
[11] SHUKUYA T,ASAO T,GOTO Y,et al. Activity and safety be provided by CD28[J]. J Exp Med,1994,179(2):709-
of atezolizumab plus carboplatin and paclitaxel in patients 713
with advanced or recurrent thymic carcinoma(MARBLE): [25]BREED E R,WATANABE M,HOGQUIST K A. Measuring

