Page 56 - 《南京医科大学学报(自然科学版)》2026年第3期
P. 56

第46卷第3期
               ·364 ·                            南 京    医 科 大 学 学         报                        2026年3月


                   thymic clonal deletion at the population level[J]. J Immu⁃  [39]PADDA S K,YAO X P,ANTONICELLI A,et al. Paraneo⁃
                   nol,2019,202(11):3226-3233                        plastic syndromes and thymic malignancies:an examina⁃
             [26]BOUILLET P,PURTON J F,GODFREY D I,et al. BH3⁃       tion of the international thymic malignancy interest group
                   only Bcl⁃2 family member Bim is required for apoptosis of  retrospective database[J]. J Thorac Oncol,2018,13(3):
                   autoreactive thymocytes[J]. Nature,2002,415(6874):  436-446
                   922-926                                      [40]BALLMAN M,ZHAO C,MCADAMS M J,et al. Immuno⁃
             [27] TOOMER K H,MALEK T R. Cytokine signaling in the    therapy for management of thymic epithelial tumors:a
                   development and homeostasis of regulatory T cells[J].  double ⁃ edged sword[J]. Cancers(Basel),2022,14(9):
                   Cold Spring Harb Perspect Biol,2018,10(3):a028597  2060
             [28]LIO C J,HSIEH C S. A two⁃step process for thymic regu⁃  [41]LIPPNER E A,LEWIS D B,ROBINSON W H,et al. Para⁃
                   latory T cell development[J]. Immunity,2008,28(1):  neoplastic and therapy⁃related immune complications in
                   100-111                                           thymic malignancies[J]. Curr Treat Options Oncol,2019,
             [29]APERT C,GALINDO⁃ALBARRÁN A O,CASTAN S,et            20(7):62
                   al. IL ⁃ 2 and IL ⁃ 15 drive intrathymic development of  [42]ISHIHARA S,OKADA S,OGI H,et al. Programmed death⁃
                                            +
                   distinct periphery ⁃ seeding CD4 Foxp3  +  regulatory T  ligand 1 expression profiling in thymic epithelial cell
                   lymphocytes[J]. Front Immunol,2022,13:965303      tumors:clinicopathological features and quantitative digi⁃
             [30]FAN M Y,TURKA L A. Immunometabolism and PI(3)K      tal image analyses[J]. Lung Cancer,2020,145:40-47
                   signaling as a link between IL⁃2,Foxp3 expression,and  [43]RAJAN A,HEERY C R,THOMAS A,et al. Efficacy and
                   suppressor function in regulatory T cells[J]. Front Immu⁃  tolerability of anti⁃programmed death⁃ligand 1(PD⁃L1)
                   nol,2018,9:69                                     antibody(Avelumab)treatment in advanced thymoma[J].
             [31]SMITH J A,YUEN B T K,PURTHA W,et al. Aire medi⁃     J Immunother Cancer,2019,7(1):269
                   ates tolerance to insulin through thymic trimming of high⁃  [44]National Cancer Institute. A pilot study to investigate the
                   affinity T cell clones[J]. Proc Natl Acad Sci USA,2024,  safety and clinical activity of avelumab(MSB0010718C)
                   121(20):e2320268121                               in thymoma and thymic carcinoma after progression on
             [32] ZHAO S J,DING J Q,WANG S Y,et al. Decreased        platinum-based chemotherapy[EB/OL].(2025-10-20)
                   expression of circulating AIRE and increased Tfh/Tfr  [2025-10-25]. https://clinicaltrials.gov/study/NCT03076
                   cells in myasthenia gravis patients[J]. Biosci Rep,2018,  554

                   38(6):BSR20180096                            [45]BRACCI L,SCHIAVONI G,SISTIGU A,et al. Immune⁃
             [33]FERNANDO R,LU Y,ATKINS S J,et al. Expression of     based mechanisms of cytotoxic chemotherapy:implica⁃
                   thyrotropin receptor,thyroglobulin,sodium ⁃ iodide sym⁃  tions for the design of novel and rationale⁃based combined
                   porter,and thyroperoxidase by fibrocytes depends on  treatments against cancer[J]. Cell Death Differ,2014,21
                   AIRE[J]. J Clin Endocrinol Metab,2014,99(7):E1236-  (1):15-25
                   E1244                                        [46]CONFORTI F,ZUCALI P A,PALA L,et al. Avelumab
             [34]MATHIS D,BENOIST C. A decade of AIRE[J]. Nat Rev    plus axitinib in unresectable or metastatic type B3 thymo⁃
                   Immunol,2007,7(8):645-650                         mas and thymic carcinomas(CAVEATT):a single⁃arm,
             [35]TATEO V,MANUZZI L,DE GIGLIO A,et al. Immunobio⁃     multicentre,phase 2 trial[J]. Lancet Oncol,2022,23
                   logy of thymic epithelial tumors:implications for immuno⁃  (10):1287-1296
                   therapy with immune checkpoint inhibitors[J]. Int J Mol  [47]REMON J,GIRARD N,NOVELLO S,et al. PECATI:a
                   Sci,2020,21(23):9056                              multicentric,open ⁃ label,single ⁃ arm phase Ⅱ study to
             [36]LIU Y M,ZHANG H,ZHANG P,et al. Autoimmune regu⁃     evaluate the efficacy and safety of pembrolizumab and
                   lator expression in thymomas with or without autoimmune  lenvatinib in pretreated B3⁃thymoma and thymic carcino⁃
                   disease[J]. Immunol Lett,2014,161(1):50-56        ma patients[J]. Clin Lung Cancer,2022,23(3):e243-e246
             [37]AO Y Q,GAO J,WANG S,et al. Immunotherapy of thymic  [48]REMON J,BIRONZO P,GIRARD N,et al. Lenvatinib
                   epithelial tumors:molecular understandings and clinical  plus pembrolizumab in pretreated metastatic B3 thymoma
                   perspectives[J]. Mol Cancer,2023,22(1):70         and thymic carcinoma(PECATI):a single⁃arm,phase 2
             [38] RADOVICH M,PICKERING C R,FELAU I,et al. The        trial[J]. Lancet Oncol,2025,26(9):1215-1226
                   integrated genomic landscape of thymic epithelial tu⁃  [49]KON E,BENHAR I. Immune checkpoint inhibitor combi⁃
                   mors[J]. Cancer Cell,2018,33(2):244-258           nations:Current efforts and important aspects for suc⁃
   51   52   53   54   55   56   57   58   59   60   61