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第46卷第3期 焦 艺,赵廷昱,刘凌翔. 胸腺上皮肿瘤免疫治疗进展与不良事件管理[J].
2026年3月 南京医科大学学报(自然科学版),2026,46(3):355-365,374 ·365 ·
cess[J]. Drug Resist Updat,2019,45:13-29 [2025-11-20]. https://clinicaltrials.gov/study/NCT04662
[50]GIRARD N,AIX S P,CEDRES S,et al. Efficacy and 294
safety of nivolumab for patients with pre⁃treated type B3 [62]SAKANE T,MURASE T,OKUDA K,et al. Expression of
thymoma and thymic carcinoma:results from the EORTC⁃ cancer testis antigens in thymic epithelial tumors[J].
ETOP NIVOTHYM phaseⅡtrial[J]. ESMO Open,2023, Pathol Int,2021,71(7):471-479
8(3):101576 [63]OJI Y,INOUE M,TAKEDA Y,et al. WT1 peptide⁃based
[51]PERRINO M,CORDUA N,DE VINCENZO F,et al. Thymic immunotherapy for advanced thymic epithelial malignan⁃
epithelial tumor and immune system:the role of immuno⁃ cies[J]. Int J Cancer,2018,142(11):2375-2382
therapy[J]. Cancers(Basel),2023,15(23):5574 [64]UMEMURA S,ZHU J Q,CHAHINE J J,et al. Downregu⁃
[52] Weill Medical College of Cornell University. A study of lation of CYLD promotes IFN⁃γ mediated PD⁃L1 expres⁃
KN046 in patients with thymic carcinoma who failed sion in thymic epithelial tumors[J]. Lung Cancer,2020,
immune checkpoint inhibitors[EB/OL].(2024-04-16) 147:221-228
[2025-10-25]. https://clinicaltrials.gov/study/NCT0492 [65]HE Y F,RAMESH A,GUSEV Y,et al. Molecular predic⁃
5947 tors of response to pembrolizumab in thymic carcinoma[J].
[53]LONG G V,DUMMER R,HAMID O,et al. Epacadostat Cell Rep Med,2021,2(9):100392
plus pembrolizumab versus placebo plus pembrolizumab [66]WEI Y F,CHU C Y,CHANG C C,et al. Different pattern
in patients with unresectable or metastatic melanoma of PD⁃L1,IDO,and FOXP3 Tregs expression with survival
(ECHO-301/KEYNOTE-252):a phase 3,randomised, in thymoma and thymic carcinoma[J]. Lung Cancer,
double ⁃ blind study[J]. Lancet Oncol,2019,20(8): 2018,125:35-42
1083-1097 [67]REPETTO M,CONFORTI F,PIROLA S,et al. Thymic
[54]Georgetown University. Pembrolizumab and epacadostat carcinoma with Lynch syndrome or microsatellite instabili⁃
in patients with thymic carcinoma[EB/OL].(2019- 12- ty,a rare entity responsive to immunotherapy[J]. Eur J
13)[2025-10-24]. https://clinicaltrials.gov/study/NCT0 Cancer,2021,153:162-167
2364076 [68] BERNARD C,FRIH H,PASQUET F,et al. Thymoma
[55]PAZ⁃ARES L,KIM T M,VICENTE D,et al. Bintrafusp associated with autoimmune diseases:85 cases and litera⁃
alfa,a bifunctional fusion protein targeting TGF ⁃ β and ture review[J]. Autoimmun Rev,2016,15(1):82-92
PD⁃L1,in second⁃line treatment of patients with NSCLC: [69] KHAN S ,GERBER D E. Autoimmunity ,checkpoint
results from an expansion cohort of a phase 1 trial[J]. J inhibitor therapy and immune ⁃ related adverse events:a
Thorac Oncol,2020,15(7):1210-1222 review[J]. Semin Cancer Biol,2020,64:93-101
[56]National Cancer Institute. A phaseⅡ,open⁃label trial of [70] KENNEDY L B,SALAMA A K S. A review of cancer
bintrafusp alfa(M7824)in subjects with thymoma and immunotherapy toxICIty[J]. CA Cancer J Clin,2020,70
thymic carcinoma[EB/OL].(2025- 09- 19)[2025- 10- (2):86-104
25]. https://clinicaltrials.gov/study/NCT04417660 [71] KONSTANTINA T,KONSTANTINOS R,ANASTASIOS
[57]THOMAS A,CHEN Y B,BERMAN A,et al. Expression K,et al. Fatal adverse events in two thymoma patients
of mesothelin in thymic carcinoma and its potential thera⁃ treated with anti⁃PD⁃1 immune check point inhibitor and
peutic significance[J]. Lung Cancer,2016,101:104-110 literature review[J]. Lung Cancer,2019,135:29-32
[58]KLAMPATSA A,DIMOU V,ALBELDA S M. Mesothelin⁃ [72] MANDALÀ M,MERELLI B,INDRIOLO A,et al. Late⁃
targeted CAR⁃T cell therapy for solid tumors[J]. Expert occurring toxICIty induced by an immune checkpoint
Opin Biol Ther,2021,21(4):473-486 blockade in adjuvant treatment of a stage Ⅲ melanoma
[59]SHAFFER D R,SAVOLDO B,YI Z Z,et al. T cells redi⁃ patient[J]. Eur J Cancer,2018,95:130-132
rected against CD70 for the immunotherapy of CD70⁃posi⁃ [73]KIM K H,HUR J Y,CHO J,et al. Immune⁃related
tive malignancies[J]. Blood,2011,117(16):4304-4314 adverse events are clustered into distinct subtypes by T⁃
[60] CHANG L J. Combination CAR⁃T cell therapy targeting cell profiling before and early after anti⁃PD⁃1 treatment[J].
hematological malignancies[EB/OL].(2025- 09- 08) Oncoimmunology,2020,9(1):1722023
[2025-10-25]. https://clinicaltrials.gov/study/NCT0312 [74]SHELLY S,AGMON⁃LEVIN N,ALTMAN A,et al. Thy⁃
5577 moma and autoimmunity[J]. Cell Mol Immunol,2011,8
[61]HUANG H. CD 70 CAR T for patients with CD70 positive (3):199-202
malignant hematologic diseases[EB/OL].(2021-11-04) (下转第374页)

