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第46卷第9期          胡羽珊,王远远,潘寅兵. C肽在1型糖尿病周围神经病变中的保护机制和临床前景[J].
                  2026年9月                     南京医科大学学报(自然科学版),2026,46(9):1294-1302                      ·1301 ·


                    ordered structured of proinsulin C ⁃ peptide in aqueous  demyelinating polyradiculoneuropathy. Report of a joint
                    solution and in the presence of lipid vesicles[J]. Cell Mol  task force of the European Federation of Neurological So⁃
                    Life Sci,2000,57(2):337-342                        cieties and the Peripheral Nerve Society[J]. J Peripher
               [25]MATTHEWS D R,RUDENSKI A S,BURNETT M A,et            Nerv Syst,2005,10(3):220-228
                    al. The half⁃life of endogenous insulin and C⁃peptide in  [37] HAANPÄÄ M,ATTAL N,BACKONJA M,et al. NeuP⁃
                    man assessed by somatostatin suppression[J]. Clin Endo⁃  SIG guidelines on neuropathic pain assessment[J].
                                                                           ®
                    crinol,1985,23(1):71-79                            PAIN ,2011,152(1):14-27
               [26]KJEMS L L,CHRISTIANSEN E,VØLUND A,et al. Vali⁃  [38]VLCKOVÁ⁃MORAVCOVÁ E,BEDNARÍK J,DUSEK L,
                    dation of methods for measurement of insulin secretion in  et al. Diagnostic validity of epidermal nerve fiber densities
                    humans in vivo[J]. Diabetes,2000,49(4):580-588     in painful sensory neuropathies[J]. Muscle Nerve,2008,
               [27]JACOBSEN L M,BUNDY B N,GRECO M N,et al. Com⁃        37(1):50-60
                    paring beta cell preservation across clinical trials in recent⁃  [39]GYLFADOTTIR S S,ITANI M,KRISTENSENA G,et al.
                    onset type 1 diabetes[J]. Diabetes Technol Ther,2020,  Assessing corneal confocal microscopy and other small
                    22(12):948-953                                     fiber measures in diabetic polyneuropathy[J]. Neurology,
               [28] FORLENZA G P,MCVEAN J,BECK R W,et al. Effect       2023,100(16):e1680-e1690
                    of verapamil on pancreatic beta cell function in newly  [40]SAMOLIS A,TROUPIS T,POLITIS C,et al. Intraepider⁃
                    diagnosed pediatric type 1 diabetes:a randomized clinical  mal nerve fiber density as an indicator of neuropathy pre⁃
                    trial[J]. JAMA,2023,329(12):990-999                disposition:a systematic review with meta⁃analysis[J]. Di⁃
               [29] YOSTEN G L C,KOLAR G R,REDLINGER L J,et al.        agnostics(Basel),2025,15(11):1311
                     Evidence for an interaction between proinsulin C⁃peptide  [41] ALAM U,JEZIORSKA M,PETROPOULOS I N,et al.
                     and GPR146[J]. J Endocrinol,2013,218(2):B1-B8     Diagnostic utility of corneal confocal microscopy and intra⁃
               [30] SHAFQAT J,JUNTTI⁃BERGGREN L,ZHONG Z,et al.         epidermal nerve fibre density in diabetic neuropathy[J].
                    Proinsulin C⁃peptide and its analogues induce intracellu⁃  PLoS One,2017,12(7):e0180175
                    lar Ca 2 +  increases in human renal tubular cells[J]. Cell  [42]QUATTRINI C,TAVAKOLI M,JEZIORSKA M,et al. Sur⁃
                    Mol Life Sci,2002,59(7):1185-1189                  rogate markers of small fiber damage in human diabetic
               [31]ZHONG Z,KOTOVA O,DAVIDESCU A,et al. C⁃peptide       neuropathy[J]. Diabetes,2007,56(8):2148-2154
                              +  +
                    stimulates Na ,K ⁃ATPase via activation of ERK1/2 MAP  [43]LØSETH S,STÅLBERG E,JORDE R,et al. Early diabetic
                    kinases in human renal tubular cells[J]. Cell Mol Life  neuropathy:thermal thresholds and intraepidermal nerve
                    Sci,2004,61(21):2782-2790                          fibre density in patients with normal nerve conduction
               [32] CIFARELLI V,GENG X,STYCHE A,et al. C⁃peptide       studies[J]. J Neurol,2008,255(8):1197-1202
                    reduces high ⁃ glucose ⁃ induced apoptosis of endothelial  [44]BRASK⁃THOMSEN P K,ITANI M,KARLSSON P,et al.
                    cells and decreases NAD(P)H⁃oxidase reactive oxygen  Development and progression of polyneuropathy over 5
                    species generation in human aortic endothelial cells[J].  years in patients with type 2 diabetes[J]. Neurology,
                    Diabetologia,2011,54(10):2702-2712                 2024,103(3):e209652
               [33]BHATT M P,LIM Y C,KIM Y M,et al. C⁃peptide acti⁃  [45]ARIMURA A,DEGUCHI T,SUGIMOTO K,et al. Intraepi⁃
                    vates AMPKα and prevents ROS⁃mediated mitochondrial  dermal nerve fiber density and nerve conduction study
                    fission and endothelial apoptosis in diabetes[J]. Diabetes,  parameters correlate with clinical staging of diabetic poly⁃

                    2013,62(11):3851-3862                              neuropathy[J]. Diabetes Res Clin Pract,2013,99(1):
               [34]LUPPI P,DRAIN P. C⁃peptide antioxidant adaptive path⁃  24-29
                    ways in β cells and diabetes[J]. J Intern Med,2017,281  [46]TIMAR B,POPESCU S,TIMAR R,et al. The usefulness
                   (1):7-24                                            of quantifying intraepidermal nerve fibers density in the
               [35] LUPPI P,CIFARELLI V,TSE H,et al. Human C⁃peptide   diagnostic of diabetic peripheral neuropathy:a cross ⁃
                    antagonises high glucose⁃induced endothelial dysfunction  sectional study[J]. Diabetol Metab Syndr,2016,8:31
                    through the nuclear factor⁃kappaB pathway[J]. Diabetolo⁃  [47]THEMISTOCLEOUS A C,RAMIREZ J D,SHILLO P R,
                    gia,2008,51(8):1534-1543                           et al. The Pain in Neuropathy Study(PiNS):a cross⁃
               [36]Joint Task Force if the EFNS and the PNS. European Fed⁃  sectional observational study determining the somatosen⁃
                    eration of Neurological Societies/Peripheral Nerve Soci⁃  sory phenotype of painful and painless diabetic neuropa⁃
                    ety Guideline on management of chronic inflammatory  thy[J]. Pain,2016,157(5):1132-1145
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