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[48] LAURIA G,BAKKERS M,SCHMITZ C,et al. Intraepi⁃ 889-897
dermal nerve fiber density at the distal leg:a worldwide [62]COTTER M A,EKBERG K,WAHREN J,et al. Effects of
normative reference study[J]. J Peripher Nerv Syst, proinsulin C⁃peptide in experimental diabetic neuropathy:
2010,15(3):202-207 vascular actions and modulation by nitric oxide synthase
[49] BHATTACHARJEE N,BARMA S,KONWAR N,et al. inhibition[J]. Diabetes,2003,52(7):1812-1817
Mechanistic insight of diabetic nephropathy and its phar⁃ [63]KAMIYA H,ZHANG W X,EKBERG K,et al. C⁃Peptide
macotherapeutic targets:an update[J]. Eur J Pharmacol, reverses nociceptive neuropathy in type 1 diabetes[J].
2016,791:8-24 Diabetes,2006,55(12):3581-3587
[50]ZENKER J,ZIEGLER D,CHRAST R. Novel pathogenic [64] JOLIVALT C G,RODRIGUEZ M,WAHREN J,et al.
pathways in diabetic neuropathy[J]. Trends Neurosci, Efficacy of a long ⁃ acting C ⁃ peptide analogue against
2013,36(8):439-449 peripheral neuropathy in streptozotocin⁃diabetic mice[J].
[51]BIERHAUS A,HASLBECK K M,HUMPERT P M,et al. Diabetes Obes Metab,2015,17(8):781-788
Loss of pain perception in diabetes is dependent on a [65]EKBERG K,BRISMAR T,JOHANSSON B L,et al. Ame⁃
receptor of the immunoglobulin superfamily[J]. J Clin lioration of sensory nerve dysfunction by C ⁃ peptide in
Invest,2004,114(12):1741-1751 patients with type 1 diabetes[J]. Diabetes,2003,52(2):
[52]HA H C,HESTER L D,SNYDER S H. Poly(ADP⁃ribose) 536-541
polymerase ⁃ 1 dependence of stress ⁃ induced transcrip⁃ [66] EKBERG K,BRISMAR T,JOHANSSON B L,et al. C⁃
tion factors and associated gene expression in Glia[J]. Peptide replacement therapy and sensory nerve function
Proc Natl Acad Sci U S A,2002,99(5):3270-3275 in type 1 diabetic neuropathy[J]. Diabetes Care,2007,30
[53] NAVE K A. Myelination and support of axonal integrity (1):71-76
by Glia[J]. Nature,2010,468(7321):244-252 [67]WAHREN J,FOYT H,DANIELS M,et al. Long⁃acting C⁃
[54] JULIUS D. TRP channels and pain[J]. Annu Rev Cell peptide and neuropathy in type 1 diabetes:a 12 ⁃ month
Dev Biol,2013,29:355-384 clinical trial[J]. Diabetes Care,2016,39(4):596-602
[55] ABBOTT C A,MALIK R A,VAN ROSS E R E,et al. [68]RAMOS E L,DAYAN C M,CHATENOUD L,et al. Tepli⁃
Prevalence and characteristics of painful diabetic neurop⁃ zumab and β ⁃cell function in newly diagnosed type 1
athy in a large community⁃based diabetic population in diabetes[J]. N Engl J Med,2023,389(23):2151-2161
the U.K[J]. Diabetes Care,2011,34(10):2220-2224 [69]TATOVIC D,MARWAHA A,TAYLOR P,et al.
[56]SUN W,MIAO B,WANG X C,et al. Reduced conduction Ustekinumab for type 1 diabetes in adolescents:a multi⁃
failure of the main axon of polymodal nociceptive C⁃fibres center,double ⁃ blind,randomized phase 2 trial[J]. Nat
contributes to painful diabetic neuropathy in rats[J]. Med,2024,30(9):2657-2666
Brain,2012,135(Pt 2):359-375 [70]VON HERRATH M,BAIN S C,BODE B,et al. Anti⁃
[57]FABER C G,HOEIJMAKERS J G,AHN H S,et al. Gain interleukin⁃21 antibody and liraglutide for the preserva⁃
of function Naν1.7 mutations in idiopathic small fiber tion of β⁃cell function in adults with recent⁃onset type 1
neuropathy[J]. Ann Neurol,2012,71(1):26-39 diabetes:a randomised,double⁃blind,placebo⁃controlled,
[58]LI Q S,CHENG P,FAVIS R,et al. SCN9A variants may phase 2 trial[J]. Lancet Diabetes Endocrinol,2021,9
be implicated in neuropathic pain associated with diabetic (4):212-224
peripheral neuropathy and pain severity[J]. Clin J Pain, [71] TAYLOR P N,COLLINS K S,LAM A,et al. C⁃peptide
2015,31(11):976-982 and metabolic outcomes in trials of disease modifying
[59]HOEIJMAKERS J G,FABER C G,MERKIES I S,et al. therapy in new⁃onset type 1 diabetes:an individual partic⁃
Channelopathies,painful neuropathy,and diabetes:which ipant meta ⁃ analysis[J]. Lancet Diabetes Endocrinol,
way does the causal arrow point?[J]. Trends Mol Med, 2023,11(12):915-925
2014,20(10):544-550 [72]ALAN M S,TAYEBI A,AFSHAR E J,et al. Association
[60]PERSSON A K,BLACK J A,GASSER A,et al. Sodium⁃ of detectable C⁃peptide levels with glycemic control and
calcium exchanger and multiple sodium channel isoforms chronic complications in individuals with type 1 diabetes
in intra⁃epidermal nerve terminals[J]. Mol Pain,2010,6:84 mellitus:a systematic review and meta⁃analysis[J]. J Dia⁃
[61]SIMA A A,ZHANG W,SUGIMOTO K,et al. C⁃peptide betes Complications,2025,39(3):108867
prevents and improves chronic Type I diabetic polyneu⁃ (收稿:2026-03-08;修回:2026-04-19;录用:2026-04-21)
ropathy in the BB/Wor rat[J]. Diabetologia,2001,44(7): (本文编辑:戴王娟)

