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第46卷第9期
               ·1302 ·                           南 京    医 科 大 学 学         报                        2026年9月


             [48] LAURIA G,BAKKERS M,SCHMITZ C,et al. Intraepi⁃      889-897
                   dermal nerve fiber density at the distal leg:a worldwide  [62]COTTER M A,EKBERG K,WAHREN J,et al. Effects of
                   normative reference study[J]. J Peripher Nerv Syst,  proinsulin C⁃peptide in experimental diabetic neuropathy:
                   2010,15(3):202-207                                vascular actions and modulation by nitric oxide synthase
             [49] BHATTACHARJEE N,BARMA S,KONWAR N,et al.            inhibition[J]. Diabetes,2003,52(7):1812-1817
                   Mechanistic insight of diabetic nephropathy and its phar⁃  [63]KAMIYA H,ZHANG W X,EKBERG K,et al. C⁃Peptide
                   macotherapeutic targets:an update[J]. Eur J Pharmacol,  reverses nociceptive neuropathy in type 1 diabetes[J].
                   2016,791:8-24                                     Diabetes,2006,55(12):3581-3587
             [50]ZENKER J,ZIEGLER D,CHRAST R. Novel pathogenic  [64] JOLIVALT C G,RODRIGUEZ M,WAHREN J,et al.
                   pathways in diabetic neuropathy[J]. Trends Neurosci,  Efficacy of a long ⁃ acting C ⁃ peptide analogue against
                   2013,36(8):439-449                                peripheral neuropathy in streptozotocin⁃diabetic mice[J].
             [51]BIERHAUS A,HASLBECK K M,HUMPERT P M,et al.          Diabetes Obes Metab,2015,17(8):781-788
                   Loss of pain perception in diabetes is dependent on a  [65]EKBERG K,BRISMAR T,JOHANSSON B L,et al. Ame⁃
                   receptor of the immunoglobulin superfamily[J]. J Clin  lioration of sensory nerve dysfunction by C ⁃ peptide in
                   Invest,2004,114(12):1741-1751                     patients with type 1 diabetes[J]. Diabetes,2003,52(2):
             [52]HA H C,HESTER L D,SNYDER S H. Poly(ADP⁃ribose)      536-541
                   polymerase ⁃ 1 dependence of stress ⁃ induced transcrip⁃  [66] EKBERG K,BRISMAR T,JOHANSSON B L,et al. C⁃
                   tion factors and associated gene expression in Glia[J].  Peptide replacement therapy and sensory nerve function
                   Proc Natl Acad Sci U S A,2002,99(5):3270-3275     in type 1 diabetic neuropathy[J]. Diabetes Care,2007,30
             [53] NAVE K A. Myelination and support of axonal integrity  (1):71-76
                   by Glia[J]. Nature,2010,468(7321):244-252    [67]WAHREN J,FOYT H,DANIELS M,et al. Long⁃acting C⁃
             [54] JULIUS D. TRP channels and pain[J]. Annu Rev Cell  peptide and neuropathy in type 1 diabetes:a 12 ⁃ month
                   Dev Biol,2013,29:355-384                          clinical trial[J]. Diabetes Care,2016,39(4):596-602
             [55] ABBOTT C A,MALIK R A,VAN ROSS E R E,et al.    [68]RAMOS E L,DAYAN C M,CHATENOUD L,et al. Tepli⁃
                   Prevalence and characteristics of painful diabetic neurop⁃  zumab and β ⁃cell function in newly diagnosed type 1
                   athy in a large community⁃based diabetic population in  diabetes[J]. N Engl J Med,2023,389(23):2151-2161
                   the U.K[J]. Diabetes Care,2011,34(10):2220-2224  [69]TATOVIC D,MARWAHA A,TAYLOR P,et al.
             [56]SUN W,MIAO B,WANG X C,et al. Reduced conduction     Ustekinumab for type 1 diabetes in adolescents:a multi⁃
                   failure of the main axon of polymodal nociceptive C⁃fibres  center,double ⁃ blind,randomized phase 2 trial[J]. Nat
                   contributes to painful diabetic neuropathy in rats[J].  Med,2024,30(9):2657-2666
                   Brain,2012,135(Pt 2):359-375                 [70]VON HERRATH M,BAIN S C,BODE B,et al. Anti⁃
             [57]FABER C G,HOEIJMAKERS J G,AHN H S,et al. Gain       interleukin⁃21 antibody and liraglutide for the preserva⁃
                   of function Naν1.7 mutations in idiopathic small fiber  tion of β⁃cell function in adults with recent⁃onset type 1
                   neuropathy[J]. Ann Neurol,2012,71(1):26-39        diabetes:a randomised,double⁃blind,placebo⁃controlled,
             [58]LI Q S,CHENG P,FAVIS R,et al. SCN9A variants may    phase 2 trial[J]. Lancet Diabetes Endocrinol,2021,9
                   be implicated in neuropathic pain associated with diabetic  (4):212-224
                   peripheral neuropathy and pain severity[J]. Clin J Pain,  [71] TAYLOR P N,COLLINS K S,LAM A,et al. C⁃peptide

                   2015,31(11):976-982                               and metabolic outcomes in trials of disease modifying
             [59]HOEIJMAKERS J G,FABER C G,MERKIES I S,et al.        therapy in new⁃onset type 1 diabetes:an individual partic⁃
                   Channelopathies,painful neuropathy,and diabetes:which  ipant meta ⁃ analysis[J]. Lancet Diabetes Endocrinol,
                   way does the causal arrow point?[J]. Trends Mol Med,  2023,11(12):915-925
                   2014,20(10):544-550                          [72]ALAN M S,TAYEBI A,AFSHAR E J,et al. Association
             [60]PERSSON A K,BLACK J A,GASSER A,et al. Sodium⁃       of detectable C⁃peptide levels with glycemic control and
                   calcium exchanger and multiple sodium channel isoforms  chronic complications in individuals with type 1 diabetes
                   in intra⁃epidermal nerve terminals[J]. Mol Pain,2010,6:84  mellitus:a systematic review and meta⁃analysis[J]. J Dia⁃
             [61]SIMA A A,ZHANG W,SUGIMOTO K,et al. C⁃peptide        betes Complications,2025,39(3):108867
                   prevents and improves chronic Type I diabetic polyneu⁃  (收稿:2026-03-08;修回:2026-04-19;录用:2026-04-21)
                   ropathy in the BB/Wor rat[J]. Diabetologia,2001,44(7):                     (本文编辑:戴王娟)
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