Page 84 - 南京医科大学学报自然科学版
P. 84
第42卷第3期
·386 · 南 京 医 科 大 学 学 报 2022年3月
的遗传学特性。本研究发现,IGHV4⁃39在中国CLL cytic leukemia/small lymphocytic lymphoma[J]. Hematol
患者中使用率高,TTFT短,并与晚期疾病、NOTCH1 Oncol,2019,37(4):392-400
突变、CD49d高表达等多种不良预后因素相关,可能 [9] INTERNATIONAL CLLIPIWG. An international prognos⁃
成为预测CLL疗效的重要指标。 tic index for patients with chronic lymphocytic leukaemia
(CLL⁃IPI):a meta⁃analysis of individual patient data[J].
[参考文献]
Lancet Oncol,2016,17(6):779-790
[1] HALLEK M,CHESON B D,CATOVSKY D,et al. IWCLL [10] YANG S M,LI J Y,GALE R P,et al. The mystery of
guidelines for diagnosis ,indications for treatment , chronic lymphocytic leukemia(CLL):Why is it absent in
response assessment,and supportive management of CLL Asians and what does this tell us about etiology,pathogen⁃
[J]. Blood,2018,131(25):2745-2760 esis and biology?[J]Blood Rev,2015,29(3):205-213
[2] YANG S,VARGHESE A M,SOOD N,et al. Ethnic and [11] MITSUI T,KOISO H,NAKAHASHI H,et al. SF3B1 and
geographic diversity of chronic lymphocytic leukaemia IGHV gene mutation status predict poor prognosis in Japa⁃
[J]. Leukemia,2021,35(2):433-439 nese CLL patients[J]. Int J Hematol,2016,103(2):219-
[3] AGATHANGELIDIS A,DARZENTAS N,HADZIDIMI⁃ 226
TRIOU A,et al. Stereotyped B⁃cell receptors in one⁃third [12] ROSSI D,SPINA V,CERRI M,et al. Stereotyped B⁃cell
of chronic lymphocytic leukemia:a molecular classifica⁃ receptor is an independent risk factor of chronic lympho⁃
tion with implications for targeted therapies[J]. Blood, cytic leukemia transformation to Richter syndrome[J].
2012,119(19):4467-4475 Clin Cancer Res,2009,15(13):4415-4422
[4] AGATHANGELIDIS A,CHATZIDIMITRIOU A,GEME⁃ [13] GOUNARI M,NTOUFA S,APOLLONIO B,et al. Exces⁃
NETZI K,et al. Higher⁃order connections between stereo⁃ sive antigen reactivity may underlie the clinical aggres⁃
typed subsets:implications for improved patient classifica⁃ siveness of chronic lymphocytic leukemia stereotyped sub⁃
tion in CLL[J]. Blood,2021,137(10):1365-1376 set #8[J]. Blood,2015,125(23):3580-3587
[5] MARINELLI M,ILARI C,XIA Y,et al. Immunoglobulin [14] ROSSI D,SPINA V,BOMBEN R,et al. Association be⁃
gene rearrangements in Chinese and Italian patients with tween molecular lesions and specific B⁃cell receptor sub⁃
chronic lymphocytic leukemia[J]. Oncotarget,2016,7 sets in chronic lymphocytic leukemia[J]. Blood,2013,
(15):20520-20531 121(24):4902-4905
[6] MIAO Y,MIAO Y,SHI K,et al. A higher percentage of [15] BENEDETTI D,TISSINO E,POZZO F,et al. NOTCH1
cells with 13q deletion predicts worse outcome in Chinese mutations are associated with high CD49d expression in
patients with chronic lymphocytic leukemia carrying iso⁃ chronic lymphocytic leukemia:link between the NOTCH1
lated 13q deletion[J]. Ann Hematol,2018,97(9):1663- and the NF ⁃ kappaB pathways[J]. Leukemia,2018,32
1669 (3):654-662
[7] XIA Y,FAN L,WANG L,et al. Frequencies of SF3B1, [16] DEL POETA G,BIAGI A,LAURENTI L,et al. Impaired
NOTCH1,MYD88,BIRC3 and IGHV mutations and nodal shrinkage and apoptosis define the independent ad⁃
TP53 disruptions in Chinese with chronic lymphocytic verse outcome of NOTCH1 mutated patients under ibruti⁃
leukemia:disparities with Europeans[J]. Oncotarget, nib therapy in chronic lymphocytic leukaemia[J]. Haema⁃
2015,6(7):5426-5434 tologica,2021,106(9):2345-2353
[8] ZOU Y X,ZHU H Y,LI X T,et al. The impacts of zanu⁃ [收稿日期] 2021-11-21
brutinib on immune cells in patients with chronic lympho⁃ (本文编辑:陈汐敏)